Melancholic major depression and epilepsy

An analysis is carried out of a set of psychic phenomena appearing always in the same way: an experience suddenly invades the consciousness, unfolding automatically and with great intensity. This psychic automatism, of which the patient is a passive observer, is accompanied by an overwhelming feeling of strangeness. Our hypothesis is that these phenomena are the expression of partial seizures with a psychic content, and the name Paroxysmal Psychic Automatisms is proposed for all of them. A comparative study is then made of the phenomenology of partial seizures with a psychic content, on the one hand, and of that of melancholic major depression, on the other. It reveals a wealth of clinical information indicating an overlap between the two conditions. Finally, a set of well-established scientific data is analysed concerning epilepsy and depression, especially epidemiological and psychopharmacological information, which takes on a new meaning in the light of the hypothesis developed in this paper. (c) 2007 Elsevier Ltd. All rights reserved.