Purified Auricularia auricular-judae polysaccharide (AAP I-a) prevents oxidative stress in an ageing mouse model

被引：91

作者：

Zhang, Hua ^{[1
]}

Wang, Zhen-Yu ^{[1
,2
]}

Zhang, Zhi ^{[2
]}

Wang, Xue ^{[3
]}

机构：

[1] Harbin Inst Technol, Sch Food Sci & Engn, Harbin 150090, Peoples R China

[2] NE Forestry Univ, Sch Forestry, Harbin 150040, Peoples R China

[3] Symrise Shanghai Co Ltd, Shanghai 201206, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2011年 / 84卷 / 01期

关键词：

Auricularia auricula-judae; Polysaccharide; Oxidative stress; Ageing mouse model; BETA-D-GLUCAN; LYCIUM-BARBARUM POLYSACCHARIDES; BLOOD LIPID-METABOLISM; ANTIOXIDANT ACTIVITY; ANTITUMOR-ACTIVITY; ANTICOAGULANT ACTIVITY; DAMAGE; VITRO; MICE; VIVO;

D O I：

10.1016/j.carbpol.2010.12.044

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This paper reports on a water-soluble polysaccharide (AAP I-a) extracted from Auricularia auricular with assistance from ultrasonics, and purified by anion-exchange and gel-permeation chromatography. Additional further structural characteristics were determined from high-performance liquid chromatography/gel permeation chromatograph (HPLC/GPC), Fourier transform infrared (FT-IR) spectrometer and gas chromatography-mass spectrophotometer (GC-MS). AAP I-a is composed of L-rhamnose, L-arabinose, D-xylose, D-mannose, D-glucose, and D-galactose in a molar ratio of 0.2:2.6:0.4:3.6:1.0:0.4. After 35 days of AAP I-a oral administration (50, 100 and 200 mg/kg once a day), the AAP I-a significantly decreased the level of malondialdehyde (MDA) and increased superoxide dismutase (SOD) and glutathione (GSH) activities in mice where ageing is induced by D-galactose (p < 0.05). In conclusion, our results indicated that AAP I-a possessed potent antioxidant activity. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

引用

页码：638 / 648

页数：11

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