Characteristics of ossification of the spinal ligament; incidence of ossification of the ligamentum flavum in patients with cervical ossification of the posterior longitudinal ligament - Analysis of the whole spine using multidetector CT

被引:51
作者
Kawaguchi, Yoshiharu [1 ]
Nakano, Masato [1 ]
Yasuda, Taketoshi [1 ]
Seki, Shoji [1 ]
Hori, Takeshi [1 ]
Suzuki, Kayo [1 ]
Makino, Hiroto [1 ]
Kimura, Tomoatsu [1 ]
机构
[1] Toyama Univ, Fac Med, Dept Orthopaed Surg, 2630 Sugitani, Toyama 9300194, Japan
关键词
THORACIC MYELOPATHY; DECOMPRESSION; RELIABILITY; FEATURES;
D O I
10.1016/j.jos.2016.04.009
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: Ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) are characterized by replacement of ligamentous tissue by ectopic new bone formation. Although the background of both diseases might be similar, there are some differences between two diseases. Some patients have both OPLL and OLF. However, the incidence of both OPLL and OLF is still unclear and the precise lesions have not been investigated, yet. This study was conducted to evaluate OLF of the whole spine in patients with cervical OPLL and to analyze the relationship of the ossified lesions between OLF and OPLL. Methods: One hundred seventy eight patients who were diagnosed as cervical OPLL by plain radiographs were included. CT images of the whole spine were taken. Ossified lesions were checked at each level of vertebral body and intervertebral disc. The ossification index of OPLL (OPLL OS index) was determined by the sum of the levels of vertebral bodies and intervertebral discs where OPLL existed. The same index was applied for detecting the level of OLF (OLF OS index). Age, gender and OPLL characteristics were compared between the OLF(+) group, OLF was seen at any levels of the spinal canal, and the OLF(-) group, OLF was not seen. Results: The most frequent level of OPLL was at C5 vertebral level and OLF was predominant at upper and lower thoracic levels. Seventeen patients (9.6%) had OPLL and OLF at the same spinal level. The averaged OPLL OS index of the total spine in these patients was 8.7 +/- 6.1, ranged from 1 to 36. The averaged OLF OS index of the total spine was 3.1 +/- 2.2 (ranged from 1 to 13) in the patients who had OLF at any levels of the whole spine. One hundred fifteen patients (64.6%) with cervical OPLL had OLF at any levels of the whole spine. No relationship was found between the OPLL OS index and the OLF OS index. There was no significant difference among the data between the OLF(+) group and the OLF(-) group. Conclusions: This study demonstrated 64.6% of the patients with cervical OPLL had OLF, mainly in the thoracic spine. However, there was no relationship regarding the severity of the ossified lesions between OPLL and OLF. CT analysis of the whole spine should be carried out for the early detection of OPLL and OLF in patients with cervical OPLL. (C) 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:439 / 445
页数:7
相关论文
共 23 条
[1]   Thoracic myelopathy caused by ossification of the ligamentum flavum: clinical features and surgical results in the Japanese population [J].
Aizawa, Tosuimi ;
Sato, Tetsuro ;
Sasaki, Hirotoshi ;
Kusakabe, Takashi ;
Morozumi, Naoki ;
Kokubun, Shoichi .
JOURNAL OF NEUROSURGERY-SPINE, 2006, 5 (06) :514-519
[2]  
Fotakopoulos G, 2010, ACTA NEUROL BELG, V110, P186
[3]   Multiple-level ossification of the ligamentum flavum in the cervical spine combined with calcification of the cervical ligamentum flavum and posterior atlanto-axial membrane [J].
Inoue, Hirokazu ;
Seichi, Atsushi ;
Kimura, Atsushi ;
Endo, Teruaki ;
Hoshino, Yuichi .
EUROPEAN SPINE JOURNAL, 2013, 22 :S416-S420
[4]   Runx2 Haploinsufficiency Ameliorates the Development of Ossification of the Posterior Longitudinal Ligament [J].
Iwasaki, Makiko ;
Piao, Jinying ;
Kimura, Ayako ;
Sato, Shingo ;
Inose, Hiroyuki ;
Ochi, Hiroki ;
Asou, Yoshinori ;
Shinomiya, Kenichi ;
Okawa, Atsushi ;
Takeda, Shu .
PLOS ONE, 2012, 7 (08)
[5]   Evaluating Agreement: Conducting a Reliability Study [J].
Karanicolas, Paul J. ;
Bhandari, Mohit ;
Kreder, Hans ;
Moroni, Antonio ;
Richardson, Martin ;
Walter, Stephen D. ;
Norman, Geoff R. ;
Guyatt, Gordon H. .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2009, 91A :99-106
[6]   A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine [J].
Karasugi, Tatsuki ;
Nakajima, Masahiro ;
Ikari, Katsunori ;
Tsuji, Takashi ;
Matsumoto, Morio ;
Chiba, Kazuhiro ;
Uchida, Kenzo ;
Kawaguchi, Yoshiharu ;
Mizuta, Hiroshi ;
Ogata, Naoshi ;
Iwasaki, Motoki ;
Maeda, Shingo ;
Numasawa, Takuya ;
Abumi, Kuniyoshi ;
Kato, Tsuyoshi ;
Ozawa, Hiroshi ;
Taguchi, Toshihiko ;
Kaito, Takashi ;
Neo, Masashi ;
Yamazaki, Masashi ;
Tadokoro, Nobuaki ;
Yoshida, Munehito ;
Nakahara, Shinnosuke ;
Endo, Kenji ;
Imagama, Shiro ;
Demura, Satoru ;
Sato, Kimiaki ;
Seichi, Atsushi ;
Ichimura, Shoichi ;
Watanabe, Masahiko ;
Watanabe, Kei ;
Nakamura, Yutaka ;
Mori, Kanji ;
Baba, Hisatoshi ;
Toyama, Yoshiaki ;
Ikegawa, Shiro .
JOURNAL OF BONE AND MINERAL METABOLISM, 2013, 31 (02) :136-143
[7]   Ossification of the Posterior Longitudinal Ligament in Not Only the Cervical Spine, but Also Other Spinal Regions Analysis Using Multidetector Computed Tomography of the Whole Spine [J].
Kawaguchi, Yoshiharu ;
Nakano, Masato ;
Yasuda, Taketoshi ;
Seki, Shoji ;
Hori, Takeshi ;
Kimura, Tomoatsu .
SPINE, 2013, 38 (23) :E1477-E1482
[8]   Variables affecting postsurgical prognosis of thoracic myelopathy caused by ossification of the ligamentum flavum [J].
Kawaguchi, Yoshiharu ;
Yasuda, Taketoshi ;
Seki, Shoji ;
Nakano, Masato ;
Kanamori, Masahiko ;
Sumi, Shigeki ;
Kimura, Tomoatsu .
SPINE JOURNAL, 2013, 13 (09) :1095-1107
[9]  
Kyongsong K, 2008, NEUROL MED CHIR, V48, P183
[10]  
Matsunaga S, 2005, CERVICAL SPINE, P1091