Elimination of different leukaemia subtypes using novel CD89-specific human cytolytic fusion proteins

被引：4

作者：

Gresch, Gerrit ^{[1
,2
]}

Schenke, Lea ^{[1
,2
]}

Mladenov, Radoslav ^{[1
]}

Zwirner, Stefan ^{[1
]}

Cremer, Christian ^{[2
]}

Niesen, Judith ^{[1
]}

Grieger, Elena ^{[1
,2
]}

Bruemmendorf, Tim ^{[3
]}

Jost, Edgar ^{[3
]}

Fischer, Rainer ^{[1
]}

Stockmeyer, Bernhard ^{[4
]}

Barth, Stefan ^{[1
,2
,5
]}

Nachreiner, Thomas ^{[2
]}

Stein, Christoph ^{[1
,2
]}

机构：

[1] Fraunhofer Inst Mol Biol & Appl Ecol IME, Dept Immunotherapy, Aachen, Germany

[2] RWTH Aachen Univ Hosp, Inst Appl Med Engn, Aachen, Germany

[3] RWTH Aachen Univ Hosp, Dept Haematol & Oncol Internal Med 4, Aachen, Germany

[4] Univ Erlangen Nurnberg, Dept Internal Med 5, Haematol Oncol, Erlangen, Germany

[5] Univ Cape Town, South African Res Chair Canc Biotechnol, Inst Infect Dis & Mol Med IDM, Dept Integrat Biomed Sci,Fac Hlth Sci, Cape Town, South Africa

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2018年 / 183卷 / 02期

关键词：

leukaemia; human cytolytic fusion proteins (hCFP); angiogenin (Ang); microtubule-associated protein tau (MapTau); single-chain Fragment variable (scFv); FC-ALPHA-RI; IMMUNOTOXIN RESISTANCE; CANCER; METHYLATION; GENERATION; ANGIOGENIN; RECEPTOR; PROMOTER; THERAPY;

D O I：

10.1111/bjh.14971

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：313 / 317

页数：5

共 10 条

[1] The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity [J].

Bakema, J. E. ;

van Egmond, M. .

MUCOSAL IMMUNOLOGY, 2011, 4 (06) :612-624

[2] Angiogenin Mutants as Novel Effector Molecules For the Generation of Fusion Proteins With Increased Cytotoxic Potential [J].

Cremer, Christian ;

Vierbuchen, Tim ;

Hein, Lea ;

Fischer, Rainer ;

Barth, Stefan ;

Nachreiner, Thomas .

JOURNAL OF IMMUNOTHERAPY, 2015, 38 (03) :85-95

[3] Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo [J].

Hristodorov, D. ;

Mladenov, R. ;

Pardo, A. ;

Pham, A-T ;

Huhn, M. ;

Fischer, R. ;

Thepen, T. ;

Barth, S. .

BRITISH JOURNAL OF CANCER, 2013, 109 (06) :1570-1578

[4] Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8 [J].

Hu, Xiaobo ;

Wei, Hui ;

Xiang, Laiman ;

Chertov, Oleg ;

Wayne, Alan S. ;

Bera, Tapan K. ;

Pastan, Ira .

LEUKEMIA RESEARCH, 2013, 37 (11) :1551-1556

[5] Humanized immunotoxins: A new generation of immunotoxins for targeted cancer therapy [J].

Mathew, Mrudula ;

Verma, Rama S. .

CANCER SCIENCE, 2009, 100 (08) :1359-1365

[6] The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia [J].

Mladenov, Radoslav ;

Hristodorov, Dmitrij ;

Cremer, Christian ;

Hein, Lea ;

Kreutzer, Fabian ;

Stroisch, Tim ;

Niesen, Judith ;

Brehm, Hannes ;

Blume, Tobias ;

Bruemmendorf, Tim Henrik ;

Jost, Edgar ;

Thepen, Theophilus ;

Fischer, Rainer ;

Stockmeyer, Bernhard ;

Barth, Stefan ;

Stein, Christoph .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (11) :2729-2738

[7]

SAXENA SK, 1992, J BIOL CHEM, V267, P21982

[8] Fc alpha RI (CD89) as a novel trigger molecule for bispecific antibody therapy [J].

Valerius, T ;

Stockmeyer, B ;

vanSpriel, AB ;

Graziano, RF ;

vandenHerikOudijk, IE ;

Repp, R ;

Deo, YM ;

Lund, J ;

Kalden, JR ;

Gramatzki, M ;

vandeWinkel, JGJ .

BLOOD, 1997, 90 (11) :4485-4492

[9] Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy [J].

Wei, Hui ;

Xiang, Laiman ;

Wayne, Alan S. ;

Chertov, Oleg ;

FitzGerald, David J. ;

Bera, Tapan K. ;

Pastan, Ira .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (18) :6898-6903

[10]

Weidle UH, 2014, CANCER GENOM PROTEOM, V11, P25

← 1 →