Location, location, timing: Analysis of cytornegalovirus epitopes for neutralizing antibodies

被引：17
作者：
Schrader, John W. [1 ]
McLean, Gary R. [1 ]
机构：
[1] Univ Texas Hlth Ctr, Houston, TX 77030 USA
来源：
IMMUNOLOGY LETTERS | 2007年 / 112卷 / 01期
关键词：
D O I：
10.1016/j.imlet.2007.07.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Attempts to produce a vaccine to human cytornegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explanation as to why most humans make antibodies to an epitope that does not always elicit neutralizing antibodies. We suggest modifications to gB for an improved HCMV vaccine design. (C) 2007 Elsevier B.V. All rights reserved.
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页码：58 / 60
页数：3
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