NR4A nuclear orphan receptors: protective in vascular disease?

被引：61

作者：

Pols, Thijs W. H. ^{[1
]}

Bonta, Peter I. ^{[1
]}

de Vries, Carlie J. M. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands

来源：

CURRENT OPINION IN LIPIDOLOGY | 2007年 / 18卷 / 05期

关键词：

atherosclerosis; inflammation; metabolism; NR4A nuclear receptors; restenosis;

D O I：

10.1097/MOL.0b013e3282ef77d1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The involvement of NR4A nuclear receptors in both metabolism and in processes in the vessel wall supports a substantial role for NR4A nuclear receptors in the development of vascular disease.

引用

页码：515 / 520

页数：6

共 46 条

[21] THE NUCLEAR RECEPTOR SUPERFAMILY - THE 2ND DECADE [J].

MANGELSDORF, DJ ;

THUMMEL, C ;

BEATO, M ;

HERRLICH, P ;

SCHUTZ, G ;

UMESONO, K ;

BLUMBERG, B ;

KASTNER, P ;

MARK, M ;

CHAMBON, P ;

EVANS, RM .

CELL, 1995, 83 (06) :835-839

[22] The NR4A subfamily of nuclear receptors:: new early genes regulated by growth factors in vascular cells [J].

Martínez-González, J ;

Badimon, L .

CARDIOVASCULAR RESEARCH, 2005, 65 (03) :609-618

[23] Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation [J].

Martínez-González, J ;

Rius, J ;

Castelló, A ;

Cases-Langhoff, C ;

Badimon, L .

CIRCULATION RESEARCH, 2003, 92 (01) :96-103

[24] Nur77 regulates lipolysis in skeletal muscle cells -: Evidence for cross-talk between the β-adrenergic and an orphan nuclear hormone receptor pathway [J].

Maxwell, MA ;

Cleasby, ME ;

Harding, A ;

Stark, A ;

Cooney, GJ ;

Muscat, GEO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (13) :12573-12584

[25]

Maxwell Megan A, 2006, Nucl Recept Signal, V4, pe002

[26] Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage [J].

Mix, Kimberlee S. ;

Attur, Mukundan G. ;

Al-Mussawir, Hayf ;

Abramson, Steven B. ;

Brinckerhoff, Constance E. ;

Murphy, Evelyn P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (13) :9492-9504

[27] The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation [J].

Nomiyama, Takashi ;

Nakamachi, Takafumi ;

Gizard, Florence ;

Heywood, Elizabeth B. ;

Jones, Karrie L. ;

Ohkura, Naganari ;

Kawamori, Ryuzo ;

Conneely, Orla M. ;

Bruemmer, Dennis .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (44) :33467-33476

[28] Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1 [J].

Ordentlich, P ;

Yan, YZ ;

Zhou, SH ;

Heyman, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) :24791-24799

[29] The orphan nuclear receptor, NOR-1, is a target of β-adrenergic signaling in skeletal muscle [J].

Pearen, Michael A. ;

Ryall, James G. ;

Maxwell, Megan A. ;

Ohkura, Naganari ;

Lynch, Gordon S. ;

Muscat, George E. O. .

ENDOCRINOLOGY, 2006, 147 (11) :5217-5227

[30] NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism [J].

Pei, Liming ;

Waki, Hironori ;

Vaitheesvaran, Bhavapriya ;

Wilpitz, Damien C. ;

Kurland, Irwin J. ;

Tontonoz, Peter .

NATURE MEDICINE, 2006, 12 (09) :1048-1055

← 1 2 3 4 5 →