The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

被引：19

作者：

Henderson, Kate N. ^{[1
]}

Reid, Hugh H. ^{[1
]}

Borg, Natalie A. ^{[1
]}

Broughton, Sophie E. ^{[1
]}

Huyton, Trevor ^{[1
]}

Anderson, Robert P. ^{[2
,3
]}

McCluskey, James ^{[4
]}

Rossjohn, Jamie ^{[1
]}

机构：

[1] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Protein Crystallograph Unit, Clayton, Vic 3800, Australia

[2] Walter & Eliza Hall Inst Med Res, Autoimmunity & Transplantat Div, Melbourne, Vic 3050, Australia

[3] Royal Melbourne Hosp, Dept Gastroenterol, Parkville, Vic, Australia

[4] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

来源：

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS | 2007年 / 63卷

关键词：

D O I：

10.1107/S1744309107051408

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.

引用

页码：1021 / 1025

页数：5

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