CS-917, a fructose 1,6-bisphosphatase inhibitor, reduces plasma glucose by suppressing hepatic glucose production, whereas metformin stimulates gastrointestinal glucose uptake

被引：0
作者：
Okuno, A. [1 ]
Tanaka, J. [1 ]
Takahashi, K. [1 ]
Ogawa, J. [1 ]
Hagisawa, Y. [1 ]
Kanda, S. [1 ]
Yoshida, T. [1 ]
机构：
[1] Daiichi Sankyo Co Ltd, Biol Res Labs 2, Tokyo, Japan
来源：
DIABETOLOGIA | 2007年 / 50卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
0218
引用
收藏
页码：S95 / S95
页数：1
相关论文
共 39 条
  • [21] Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose:: Roles of malic enzyme and fructose-1,6-bisphosphatase
    Georgi, T
    Rittmann, D
    Wendisch, VF
    METABOLIC ENGINEERING, 2005, 7 (04) : 291 - 301
  • [22] Oxazole phosphonic acids as fructose 1,6-bisphosphatase inhibitors with potent glucose-lowering activity
    Dang, Qun
    Kasibthatla, Srinivas Rao
    Jiang, Tao
    Taplin, Frank
    Gibson, Tony
    Potter, Scott C.
    van Poelje, Paul D.
    Erion, Mark D.
    MEDCHEMCOMM, 2011, 2 (04) : 287 - 290
  • [23] INDUCTION OF FRUCTOSE 1,6-BISPHOSPHATASE AND GLUCOSE 6-PHOSPHATASE IN FETAL MOUSE-LIVER
    TASHIMA, Y
    MIZUNUMA, H
    KUMEGAWA, M
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 220 (02) : 379 - 385
  • [24] CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats
    Yoshida, Taishi
    Okuno, Akira
    Izumi, Masanori
    Takahashi, Kanako
    Hagisawa, Yuka
    Ohsumi, Jun
    Fujiwara, Toshihiko
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 601 (1-3) : 192 - 197
  • [25] Glucose lowering and antidiabetic activity of a potent and selective inhibitor of fructose 1,6-bisphosphatase (MB06322) in normal and diabetic rodents
    Potter, SC
    van Poelje, PD
    Fujitaki, JM
    Pankop, M
    Dang, Q
    Erion, MD
    DIABETOLOGIA, 2004, 47 : A70 - A71
  • [26] Protein Kinase CK2 Contributes to Glucose Homeostasis by Targeting Fructose-1,6-Bisphosphatase 1
    Pack, Mandy
    Gulde, Tim Nikolai
    Voelcker, Michelle Victoria
    Boewe, Anne S.
    Wrublewsky, Selina
    Ampofo, Emmanuel
    Montenarh, Mathias
    Goetz, Claudia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
  • [27] Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in mouse liver leads to suppression of hepatic glucose production and lowered blood glucose
    Wu, CD
    Liao, QN
    Okar, DA
    Newgard, CB
    Lange, AJ
    DIABETES, 2000, 49 : A291 - A292
  • [28] MB07803, a prodrug of a second generation fructose-1,6-bisphosphatase inhibitor, lowers blood glucose in diabetic rodents and in cynomolgus monkeys
    Van Poelje, Paul D.
    Potter, Scott C.
    Fujitaki, James M.
    Dang, Qun
    Linemeyer, David L.
    Erion, Mark D.
    DIABETES, 2008, 57 : A101 - A101
  • [29] Silencing of Fructose 1,6-Bisphosphatase (FBP1) in Liver Improves Glucose Homeostasis in Insulin-Resistant Rodent and Human Models
    Fledelius, Christian
    Iversen, Helle
    Ingvorsen, Rikke S.
    Eriksen, Lisbeth B.
    Blois, Anna
    Montauban, Yvenet
    Rijnbrand, Rene
    Han, Wen
    Jeppesen, Jacob F.
    Demozay, Damien
    DIABETES, 2022, 71
  • [30] Fructose 1,6-bisphosphatase inhibition improves oral glucose tolerance and enhances the antidiabetic action of glyburide in the Zucker diabetic fatty rat
    Erion, MD
    Potter, SC
    van Poelje, PD
    DIABETOLOGIA, 2004, 47 : A288 - A288
1234