One-year mortality and consequences of COVID-19 in cancer patients: A cohort study

被引：36

作者：

Chai, Chen ^{[1
]}

Feng, Xiaojun ^{[2
]}

Lu, Meixia ^{[3
]}

Li, Shoupeng ^{[1
]}

Chen, Kui ^{[4
]}

Wang, Hongxiang ^{[5
]}

Wang, Wendan ^{[1
]}

Tang, Zhaoming ^{[6
]}

Cheng, Gang ^{[7
]}

Wu, Xiaoxiong ^{[1
]}

Li, Yunfeng ^{[1
]}

Wen, Yuying ^{[1
]}

Da, Banghong ^{[1
]}

Fan, Hong ^{[1
]}

Wang, Lei ^{[1
]}

Ai, Fen ^{[8
]}

Li, Wei ^{[8
]}

Peng, Cao ^{[1
]}

Zhang, Hongrong ^{[1
]}

Wen, Shuang ^{[1
]}

Zhang, Jinnong ^{[1
]}

Weng, Yuxiong ^{[9
,10
]}

Tang, Zehai ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Emergency Med, Tongji Med Coll, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China

[2] NYU Langone Med Ctr, Dept Pathol, New York, NY USA

[3] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Tongji Med Coll, Wuhan, Peoples R China

[4] Hubei Univ Med, Affiliated Dongfeng Hosp, Dept Emergency Med, Shiyan, Hubei, Peoples R China

[5] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Hematol, Tongji Med Coll, Wuhan, Peoples R China

[6] Huazhong Univ Sci & Technol, Union Hosp, Dept Lab Med, Tongji Med Coll, Wuhan, Peoples R China

[7] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Comp Ctr, Wuhan, Peoples R China

[8] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Emergency Med, Tongji Med Coll, Wuhan, Peoples R China

[9] Huazhong Univ Sci & Technol, Union Hosp, Dept Med Adm, Tongji Med Coll, Wuhan, Peoples R China

[10] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan, Peoples R China

来源：

IUBMB LIFE | 2021年 / 73卷 / 10期

关键词：

Cancer; consequences; coronavirus disease 2019; mortality; risk factors; OUTCOMES;

D O I：

10.1002/iub.2536

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1-year mortality and health consequences of COVID-19 in cancer patients are relatively underexplored. In this multicenter cohort study, 166 COVID-19 patients with cancer were compared with 498 non-cancer COVID-19 patients and 498 non-COVID cancer patients. The 1-year all-cause mortality and hospital mortality rates in Cancer COVID-19 Cohort (30% and 20%) were significantly higher than those in COVID-19 Cohort (9% and 8%, both P < .001) and Cancer Cohort (16% and 2%, both P < 0.001). The 12-month all-cause post-discharge mortality rate in survival discharged Cancer COVID-19 Cohort (8%) was higher than that in COVID-19 Cohort (0.4%, P < .001) but similar to that in Cancer Cohort (15%, P = .084). The incidence of sequelae in Cancer COVID-19 Cohort (23%, 26/114) is similar to that in COVID-19 Cohort (30%, 130/432, P = .13). The 1-year all-cause mortality was high among patients with hematologic malignancies (59%), followed by those who have nasopharyngeal, brain, and skin tumors (45%), digestive system neoplasm (43%), and lung cancers (32%). The rate was moderate among patients with genitourinary (14%), female genital (13%), breast (11%), and thyroid tumors (0). COVID-19 patients with cancer showed a high rate of in-hospital mortality and 1-year all-cause mortality, but the 12-month all-cause post-discharge mortality rate in survival discharged cancer COVID-19 patients was similar to that in Cancer Cohort. Comparing to COVID-19 Cohort, risk stratification showed that hematologic, nasopharyngeal, brain, digestive system, and lung tumors were high risk (44% vs 9%, P < 0.001), while genitourinary, female genital, breast, and thyroid tumors had moderate risk (10% vs 9%, P = .85) in COVID-19 Cancer Cohort. Different tumor subtypes had different effects on COVID-19. But if cancer patients with COVID-19 manage to survive their COVID-19 infections, then long-term mortality appears to be similar to the cancer patients without COVID-19, and their long-term clinical sequelae were similar to the COVID-19 patients without cancer.

引用

页码：1244 / 1256

页数：13

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