One-Pot Double Suzuki Couplings of Dichloropyrimidines

被引：27

作者：

Anderson, Samantha C. ^{[1
]}

Handy, Scott T. ^{[1
]}

机构：

[1] Middle Tennessee State Univ, Dept Chem, Murfreesboro, TN 37132 USA

来源：

SYNTHESIS-STUTTGART | 2010年 / 16期

关键词：

pyrimidines; Suzuki coupling; regioselectivity; palladium-catalyzed; one-pot reaction; HALOGENATED NITROGEN; FUNCTIONALIZATION; REGIOSELECTIVITY; HETEROCYCLES; PYRIMIDINES; INHIBITORS; ARYLATION; OXYGEN; ACIDS;

D O I：

10.1055/s-0030-1258150

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and requiring correspondingly lower temperatures than the use of polar aprotic solvents.

引用

页码：2721 / 2724

页数：4

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