Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins

被引：15

作者：

Deng, Zhi-Xiong ^{[1
]}

Zheng, Yu ^{[1
]}

Xie, Zhen-Zhen ^{[1
]}

Gao, Yue-Heng ^{[1
]}

Xiao, Jun-An ^{[3
]}

Xie, Si-Qi ^{[1
]}

Xiang, Hao-Yue ^{[1
]}

Chen, Xiao-Qing ^{[1
,2
]}

Yang, Hua ^{[1
,2
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Cent South Univ, Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Peoples R China

[3] Nanning Normal Univ, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 02期

基金：

中国国家自然科学基金;

关键词：

UMPOLUNG; CYCLOADDITION; ALLENOATES;

D O I：

10.1021/acs.orglett.9b04248

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report a phosphine-mediated domino process of MBH-type reaction/umpolung gamma-addition through the rational integration of the privileged reactivities of alkynoate. Simply by manipulating the nucleophilic reagent, the developed protocol offers a facile, diversity-oriented construction of a wide range of three-substituted coumarins.

引用

页码：488 / 492

页数：5

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