Withanolides from Aureliana fasciculata var. fasciculata

被引：18
作者：
Almeida-Lafeta, Rita C. [2 ]
Ferreira, Marcelo J. P. [1 ]
Emerenciano, Vicente P. [3 ]
Kaplan, Maria A. C. [2 ]
机构：
[1] Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo, Brazil
[2] Univ Fed Rio de Janeiro, Nucleo Pesquisas Prod Nat, BR-21941590 Rio De Janeiro, Brazil
[3] Univ Sao Paulo, Inst Quim, BR-05513970 Sao Paulo, Brazil
来源：
HELVETICA CHIMICA ACTA | 2010年 / 93卷 / 12期
基金：
巴西圣保罗研究基金会;
关键词：
ERGOSTANE-TYPE STEROIDS; WITHANIA-SOMNIFERA; TACCA-PLANTAGINEA; AJUGA-PARVIFLORA; PHYSALIS-PHILADELPHICA; ACNISTUS-ARBORESCENS; QUINONE REDUCTASE; DISCOPODIUM-PENNINERVIUM; SALPICHROA-ORIGANIFOLIA; CYTOTOXIC WITHANOLIDES;
D O I：
10.1002/hlca.201000126
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the first phytochemical study of the Aureliana genus (Solanaceae), two new withanolides, 1 and 2, together with two known sterols, were isolated from the MeOH extract of the leaves of Aureliana fasciculata var. fasciculata. The structures were established as (4S,22R)-16 alpha-acetoxy-5 beta,6 beta-epoxy-4 beta,17 alpha-dihydroxy-1-oxowitha-2,24-dienolide (aurelianolide A) and (4S,22R)-16 alpha-acetoxy-4 beta,17 alpha-dihydroxy-1-oxowitha-2,5,24-trienolide (aurelianolide B). The new compounds possessed the unusual 16 alpha,17 alpha-dioxygenated group and were fully characterized by spectroscopic techniques, including H-1- and C-13-NMR (DEPT), as well as 2D-NMR (HMBC, HMQC, H-1, H-1-COSY, NOESY) experiments, and HR-MS.
引用
收藏
页码：2478 / 2487
页数：10
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