Fe3+@polyDOPA-b-polysarcosine, a T1-Weighted MRI Contrast Agent via Controlled NTA Polymerization

被引：55

作者：

Miao, Yuedong ^{[1
]}

Xie, Fengnan ^{[2
,3
]}

Cen, Jiayu ^{[1
]}

Zhou, Fei ^{[2
]}

Tao, Xinfeng ^{[1
]}

Luo, Jingfeng ^{[2
]}

Han, Guocan ^{[2
]}

Kong, Xianglei ^{[2
]}

Yang, Xiaoming ^{[2
]}

Sun, Jihong ^{[2
,4
]}

Ling, Jun ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Radiol, Hangzhou 310016, Zhejiang, Peoples R China

[3] Hangzhou Med Coll, Dept Med Imagine, Hangzhou 310053, Zhejiang, Peoples R China

[4] Zhejiang Univ, Innovat Ctr Minimally Invas Tech & Device, Hangzhou 310016, Zhejiang, Peoples R China

来源：

ACS MACRO LETTERS | 2018年 / 7卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ACID-N-CARBOXYANHYDRIDES; NEPHROGENIC SYSTEMIC FIBROSIS; RING-OPENING POLYMERIZATION; MAGNETIC NANOPARTICLES; BLOCK COPOLYPEPTIDES; COPOLYMERS SYNTHESIS; DRUG-DELIVERY; GENE DELIVERY; POLYPEPTIDE; COMPLEXES;

D O I：

10.1021/acsmacrolett.8b00287

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

alpha-Amino acid N-thiocarboxyanhydrides (NTAs) are promising cyclic monomers to synthesize polypeptides and polypeptoids via controlled ring-opening polymerizations. Superior to N-carboxyanhydrides requiring protection on hydroxyl groups, NTAs are able to tolerate such nucleophiles. In this work, we report the synthesis of NTA monomers containing unprotected phenolic hydroxyl groups of 3,4-dihydroxy-L-phenylalanine (DOPA) and L-tyrosine (Tyr). Their controlled ROPs and sequential copolymerizations with polysarcosine (PSar) yield PDOPA, PTyr, and PDOPA-b-polysarcosine (PDOPA-b-PSar) products quantitatively with designable degrees of polymerization. Micellar nanoparticles of Fe3+@PDOPA-b-PSar have been prepared thanks to the strong chelation of iron(III) cation by catechol ligands that act as T1-weighted magnetic resonance imaging (MRI) contrast agents. For instance, Fe3+@PDOPA(10)b-PSar(50) exhibits higher longitudinal relaxivity (r(1) = 5.6 mM(-1) s(-1)) than commercial Gd3+-based compounds. Effective MRI contrast enhancement in vivo of nude mice with a moderate duration (150 min) and 3D magnetic resonance angiography in rabbit illustrated by using volume rendering and maximal intensity projection techniques ignite the clinical application of Fe3+-based polypept(o)ides in diagnostic radiology as Gd-free MRI contrast agents.

引用

页码：693 / 698

页数：11

共 58 条

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