ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

被引：1435

作者：

Ashkenazy, Haim ^{[1
,2
]}

Erez, Elana ^{[1
,2
]}

Martz, Eric ^{[3
]}

Pupko, Tal ^{[2
]}

Ben-Tal, Nir ^{[1
]}

机构：

[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel

[3] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

关键词：

IDENTIFICATION; SUBSTITUTION; ALIGNMENT; MODEL; GENERATION; PHYLOGENY; RESIDUES; REGIONS; GAL4;

D O I：

10.1093/nar/gkq399

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf (http://consurf.tau.ac.il) and ConSeq (http://conseq.tau.ac.il) are two well-established web servers for calculating the evolutionary conservation of amino acid positions in proteins using an empirical Bayesian inference, starting from protein structure and sequence, respectively. Here, we present the new version of the ConSurf web server that combines the two independent servers, providing an easier and more intuitive step-by-step interface, while offering the user more flexibility during the process. In addition, the new version of ConSurf calculates the evolutionary rates for nucleic acid sequences. The new version is freely available at: http://consurf.tau.ac.il/.

引用

页码：W529 / W533

页数：5

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