Lack of response to nivolumab in a patient with EGFR-mutant non-small cell lung cancer adenocarcinoma sub-type transformed to small cell lung cancer

被引：22

作者：

Tokaca, Nadza ^{[1
]}

Wotherspoon, Andrew ^{[2
]}

Nicholson, Andrew G. ^{[3
,4
]}

Fotiadis, Nicos ^{[5
]}

Thompson, Lisa ^{[6
]}

Popat, Sanjay ^{[1
,4
]}

机构：

[1] Royal Marsden Hosp, Lung Unit, Fulham Rd, London SW3 6JJ, England

[2] Royal Marsden Hosp, Dept Histopathol, Fulham Rd, London SW3 6JJ, England

[3] Royal Marsden Hosp, Dept Histopathol, Fulham Rd,Sydney St, London SW3 6NP, England

[4] Imperial Coll London, Natl Heart & Lung Inst, Cale St, London SW3 6LY, England

[5] Royal Marsden Hosp, Dept Intervent Radiol, Fulham Rd, London SW3 6JJ, England

[6] Inst Canc Res, Ctr Mol Pathol, Downs Rd, Sutton SM2 5PT, Surrey, England

来源：

LUNG CANCER | 2017年 / 111卷

关键词：

NSCLC; Adenocarcinoma; EGFR; Small cell lung cancer; Transformation; Nivolumab; RESISTANCE MECHANISM; DOCETAXEL;

D O I：

10.1016/j.lungcan.2017.07.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small cell transformation is a rare but well recognised mechanism of acquired resistance to EGFR-TKI therapy in EGFR-mutated NSCLC, but optimal drug therapy thereof is unknown. Nivolumab has demonstrated activity in relapsed de novo small cell lung cancer in early phase trials. Here, we report a case of transformed EGFR-mutant SCLC treated with nivolumab with no benefit.

引用

页码：65 / 68

页数：4

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