The prognostic significance of microRNA-221 in hepatocellular carcinoma: An updated meta-analysis

被引：7
作者：
Liu, Wenfeng [1 ]
Hu, Keshu [1 ]
Zhang, Feng [1 ]
Lu, Shenxin [1 ]
Chen, Rongxin [1 ]
Ren, Zhenggang [1 ]
Yin, Xin [1 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, 136 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2021年 / 36卷 / 02期
关键词：
miR-221; hepatocellular carcinoma; prognostic biomarker; THERAPEUTIC STRATEGIES; MIR-221; EXPRESSION; MIRNA; PROLIFERATION; SUPPRESSION; BIOMARKERS; RESISTANCE; INVASION;
D O I：
10.1177/17246008211032689
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background Recently, microRNA-221 has been found to be abnormally expressed in hepatocellular carcinoma; however, its clinical value has not been summarised. This meta-analysis aimed to assess the prognostic significance of miR-221 in hepatocellular carcinoma. Material and Methods PubMed, Science Direct, Web of Science, Scopus, Ovid MEDLINE, EMbase, Google Scholar, the Cochrane Library, CNKI, CBM, VIP and Wanfang databases were searched for eligible articles. The endpoints included overall survival, progression-free survival, recurrence-free survival, metastasis-free survival, disease-free survival. Hazard ratios with 95% confidence intervals were used to explore the relationship between miR-221 expression and clinical survival results of liver cancer patients. Subgroup analysis and sensitivity analysis were performed. Begg's test and Egger's test were conducted to evaluate publication bias. Results A total of nine studies including 607 patients were recruited for this meta-analysis. The pooled hazard ratios displayed that high miR-221 expression was remarkably associated with poorer overall survival (hazard ratio = 1.91, 95% confidence interval: 1.53-2.38, p < 0.01) and unfavourable progression-free survival/recurrence-free survival/metastasis-free survival/disease-free survival (hazard ratio = 2.02, 95% confidence interval: 1.58-2.57, p < 0.01). The results of Begg's test and Egger's test did not exhibit obvious publication bias. Conclusions High expression of miR-221 can predict poor outcome of hepatocellular carcinoma. miR-221 can be used as a promising prognostic biomarker of hepatocellular carcinoma.
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页数：8
相关论文
共 38 条
[1]   MicroRNA expression profiling: A molecular tool for defining, the phenotype of hepatocellular tumors [J].
Braconi, Chiara ;
Patel, Tushar .
HEPATOLOGY, 2008, 47 (06) :1807-1809
[2]  
Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
[3]   Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221 [J].
Brognara, Eleonora ;
Fabbri, Enrica ;
Bazzoli, Elena ;
Montagner, Giulia ;
Ghimenton, Claudio ;
Eccher, Albino ;
Cantu, Cinzia ;
Manicardi, Alex ;
Bianchi, Nicoletta ;
Finotti, Alessia ;
Breveglieri, Giulia ;
Borgatti, Monica ;
Corradini, Roberto ;
Bezzerri, Valentino ;
Cabrini, Giulio ;
Gambari, Roberto .
JOURNAL OF NEURO-ONCOLOGY, 2014, 118 (01) :19-28
[4]   Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma [J].
Chen, Fan ;
Li, Xin-Feng ;
Fu, Dong-Sheng ;
Huang, Jian-Guo ;
Yang, Shun-E .
CANCER BIOMARKERS, 2017, 18 (02) :209-214
[5]   Liver cancer epidemic in China: Past, present and future [J].
Chen, Jian Guo ;
Zhang, Si Wei .
SEMINARS IN CANCER BIOLOGY, 2011, 21 (01) :59-69
[6]   HBx protein-induced upregulation of microRNA-221 promotes aberrant proliferation in HBV-related hepatocellular carcinoma by targeting estrogen receptor-α [J].
Chen, Juan-Juan ;
Tang, Yi-Shu ;
Huang, Shi-Feng ;
Ai, Jian-Gang ;
Wang, Hai-Xia ;
Zhang, Li-Ping .
ONCOLOGY REPORTS, 2015, 33 (02) :792-798
[7]   miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27Kip1- and MEK/ERK-mediated cell cycle regulation [J].
Dai, Rongyang ;
Li, Juan ;
Liu, Youping ;
Yan, Dongmei ;
Chen, Shaokun ;
Duan, Chunyan ;
Liu, Xiaoyan ;
He, Tao ;
Li, Hong .
BIOLOGICAL CHEMISTRY, 2010, 391 (07) :791-801
[8]   MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma [J].
Fang, YuXiang ;
Xue, Jing-Lun ;
Shen, Qi ;
Chen, Jinzhong ;
Tian, Ling .
HEPATOLOGY, 2012, 55 (06) :1852-1862
[9]   MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma [J].
Fornari, F. ;
Gramantieri, L. ;
Ferracin, M. ;
Veronese, A. ;
Sabbioni, S. ;
Calin, G. A. ;
Grazi, G. L. ;
Giovannini, C. ;
Croce, C. M. ;
Bolondi, L. ;
Negrini, M. .
ONCOGENE, 2008, 27 (43) :5651-5661
[10]   In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3-Mediated Apoptosis [J].
Fornari, Francesca ;
Pollutri, Daniela ;
Patrizi, Clarissa ;
La Bella, Tiziana ;
Marinelli, Sara ;
Gardini, Andrea Casadei ;
Marisi, Giorgia ;
Toaldo, Marco Baron ;
Baglioni, Michele ;
Salvatore, Veronica ;
Callegari, Elisa ;
Baldassarre, Maurizio ;
Galassi, Marzia ;
Giovannini, Catia ;
Cescon, Matteo ;
Ravaioli, Matteo ;
Negrini, Massimo ;
Bolondi, Luigi ;
Gramantieri, Laura .
CLINICAL CANCER RESEARCH, 2017, 23 (14) :3953-3965
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