Muscle growth learns new tricks from an old dog

被引：8
作者：
Nader, Gustavo A. [1 ]
机构：
[1] Childrens Natl Med Ctr, Res Ctr Genet Med, Washington, DC 20010 USA
来源：
NATURE MEDICINE | 2007年 / 13卷 / 09期
关键词：
D O I：
10.1038/nm0907-1016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The S6K1 kinase lies downstream of a signaling network crucial for muscle hypertrophy. It now seems that S6K1 also interacts with another kinase - AMPK - to integrate muscle-cell growth with metabolic regulation.
引用
收藏
页码：1016 / 1018
页数：4
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共 10 条
  • [1] S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase
    Aguilar, Victor
    Alliouachene, Samira
    Sotiropoulos, Athanassia
    Sobering, Andrew
    Athea, Yoni
    Djouadi, Fatima
    Miraux, Sylvain
    Thiaudiere, Eric
    Foretz, Marc
    Viollet, Benoit
    Diolez, Philippe
    Bastin, Jean
    Benit, Paule
    Rustin, Pierre
    Carling, David
    Sandri, Marco
    Ventuar-Clapier, Renee
    Pende, Mario
    [J]. CELL METABOLISM, 2007, 5 (06) : 476 - 487
  • [2] Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    Bodine, SC
    Stitt, TN
    Gonzalez, M
    Kline, WO
    Stover, GL
    Bauerlein, R
    Zlotchenko, E
    Scrimgeour, A
    Lawrence, JC
    Glass, DJ
    Yancopoulos, GD
    [J]. NATURE CELL BIOLOGY, 2001, 3 (11) : 1014 - 1019
  • [3] AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
    Bolster, DR
    Crozier, SJ
    Kimball, SR
    Jefferson, LS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) : 23977 - 23980
  • [4] Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
    Chan, AYM
    Soltys, CLM
    Young, ME
    Proud, CG
    Dyck, JRB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (31) : 32771 - 32779
  • [5] Skeletal muscle hypertrophy and atrophy signaling pathways
    Glass, DJ
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (10) : 1974 - 1984
  • [6] TSC2 mediates cellular energy response to control cell growth and survival
    Inoki, K
    Zhu, TQ
    Guan, KL
    [J]. CELL, 2003, 115 (05) : 577 - 590
  • [7] AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    Kahn, BB
    Alquier, T
    Carling, D
    Hardie, DG
    [J]. CELL METABOLISM, 2005, 1 (01) : 15 - 25
  • [8] S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
    Mieulet, Virginie
    Roceri, Mila
    Espeillac, Catherine
    Sotiropoulos, Athanassia
    Ohanna, Mickael
    Oorschot, Viola
    Klumperman, Judith
    Sandri, Marco
    Pende, Mario
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 293 (02): : C712 - C722
  • [9] Molecular determinants of skeletal muscle mass: getting the "AKT" together
    Nader, GA
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (10) : 1985 - 1996
  • [10] Atrophy of S6K1-/- skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
    Ohanna, M
    Sobering, AK
    Lapointe, T
    Lorenzo, L
    Praud, C
    Petroulakis, E
    Sonenberg, N
    Kelly, PA
    Sotiropoulos, A
    Pende, M
    [J]. NATURE CELL BIOLOGY, 2005, 7 (03) : 286 - 294
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