Is cell surface calreticulin involved in phagocytosis by insect hemocytes?

被引：51

作者：

Asgari, S ^{[1
]}

Schmidt, O ^{[1
]}

机构：

[1] Univ Adelaide, Dept Appl & Mol Ecol, Glen Osmond, SA 5064, Australia

来源：

JOURNAL OF INSECT PHYSIOLOGY | 2003年 / 49卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

phagocytosis; calreticulin; Pieris rapae; Galleria mellonella; Ephestia kuhniella;

D O I：

10.1016/S0022-1910(03)00025-8

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

The innate immune system of insects consists of humoral and cellular components involved in the recognition of and responses to intruding foreign micro- or macroorganisms. Several molecules have been identified so far that recognize molecular patterns present on microorganisms, such as lipopolysaccharides, peptidoglycans and lipoteichonic acid. These molecules, acting as opsonins, trigger immune responses such as phagocytosis, nodule formation, melanization and encapsulation. Here, we investigated the role of calreticulin (CRT) present on the surface of Pieris rapae hemocytes in phagocytosis. Comparative phagocytosis assays using yeast cells showed that hemocytes from different insects exhibit significant variation in their phagocytosing potential and relative CRT involvement. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：545 / 550

页数：6

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