Chlamydia pneumoniae and Oxidative Stress in Cardiovascular Disease: State of the Art and Prevention Strategies

被引:22
作者
Di Pietro, Marisa [1 ]
Filardo, Simone [1 ]
De Santis, Fiorenzo [1 ]
Mastromarino, Paola [1 ]
Sessa, Rosa [1 ]
机构
[1] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy
关键词
C; pneumoniae; cardiovascular disease; oxidative stress; prevention strategies; SMOOTH-MUSCLE-CELLS; ATHEROSCLEROTIC LESION DEVELOPMENT; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL-CELLS; ACCELERATED ATHEROSCLEROSIS; ANTIOXIDANT ENZYMES; CYTOKINE PRODUCTION; INFECTION;
D O I
10.3390/ijms16010724
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chlamydia pneumoniae, a pathogenic bacteria responsible for respiratory tract infections, is known as the most implicated infectious agent in atherosclerotic cardiovascular diseases (CVDs). Accumulating evidence suggests that C. pneumoniae-induced oxidative stress may play a critical role in the pathogenesis of CVDs. Indeed, the overproduction of reactive oxygen species (ROS) within macrophages, endothelial cells, platelets and vascular smooth muscle cells (VSMCs) after C. pneumoniae exposure, has been shown to cause low density lipoprotein oxidation, foam cell formation, endothelial dysfunction, platelet adhesion and aggregation, and VSMC proliferation and migration, all responsible for the typical pathological changes of atherosclerotic plaque. The aim of this review is to improve our insight into C. pneumoniae-induced oxidative stress in order to suggest potential strategies for CVD prevention. Several antioxidants, acting on multi-enzymatic targets related to ROS production induced by C. pneumoniae, have been discussed. A future strategy for the prevention of C. pneumoniae-associated CVDs will be to target chlamydial HSP60, involved in oxidative stress.
引用
收藏
页码:724 / 735
页数:12
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