Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives

被引：9

作者：

Alekseeva, T. P. ^{[1
]}

Rakhmetova, A. A. ^{[2
]}

Bogoslovskaya, O. A. ^{[1
]}

Olkhovskaya, I. P. ^{[1
]}

Levov, A. N.

Il'ina, A. V. ^{[3
]}

Varlamov, V. P. ^{[3
]}

Baitukalov, T. A. ^{[4
]}

Glushchenko, N. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Energy Problems Chem Phys, Moscow 119334, Russia

[2] Peoples Friendship Univ Russia, Moscow 117198, Russia

[3] Russian Acad Sci, Ctr Bioinzeneria, Moscow 117312, Russia

[4] Familiprix Lasalle, Montreal, PQ 9316, Canada

来源：

BIOLOGY BULLETIN | 2010年 / 37卷 / 04期

关键词：

Chitosan; Wound Healing; Chitin; Biology Bulletin; Maleic Anhydride;

D O I：

10.1134/S1062359010040023

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0.05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control.

引用

页码：339 / 345

页数：7

共 29 条

[1] Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications [J].

Alves, N. M. ;

Mano, J. F. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 43 (05) :401-414

[2]

BAYTUKALOV TA, 2005, IZV AKAD NAUK BIOL+, V32, P659

[3] WOUND MANAGEMENT WITH N-CARBOXYBUTYL CHITOSAN [J].

BIAGINI, G ;

BERTANI, A ;

MUZZARELLI, R ;

DAMADEI, A ;

DIBENEDETTO, G ;

BELLIGOLLI, A ;

RICCOTTI, G ;

ZUCCHINI, C ;

RIZZOLI, C .

BIOMATERIALS, 1991, 12 (03) :281-286

[4] N-(3-sulfo, 3-carboxy)-propionylchitosan as new chiral selector for enantioresolution of basic drugs by capillary electrophoresis [J].

Budanova, N ;

Shapovalova, E ;

Lopatin, S ;

Varlamov, V ;

Shpigun, O .

CHROMATOGRAPHIA, 2004, 59 (11-12) :709-713

[5]

BYKOVA VM, 2002, KHITIN KHITOZAN

[6] Chitosan inhibits prostaglandin E2 formation and cyclooxygenase-2 induction in lipopolysaccharide-treated RAW 264.7 macrophages [J].

Chou, TC ;

Fu, E ;

Shen, EC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 308 (02) :403-407

[7]

Clark D., 1996, Guide for the Care and Use of Laboratory Animals

[8] Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns [J].

Dai, Tianhong ;

Tegos, George P. ;

Burkatovskaya, Marina ;

Castano, Ana P. ;

Hamblin, Michael R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (02) :393-400

[9]

DROZD NN, 2002, KHITIN KHITOZAN POLU

[10]

EREMEEV AV, 2008, SOVREMENNYE PERSPEKT, P169

← 1 2 3 →