1,3,4-Thiadiazoles: A potent multi targeted pharmacological scaffold

被引：150

作者：

Haider, Saqlain ^{[1
,2
]}

Alam, Mohammad Samar ^{[2
]}

Hamid, Hinna ^{[2
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Jamia Hamdard, Fac Sci, Dept Chem, New Delhi 110062, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 92卷

关键词：

1,3,4-Thiadiazole; Mesoionic; Syndones; Anticancer; Anti-inflammatory; Hyperlipidaemia; CARBONIC-ANHYDRASE INHIBITORS; ANTI-HIV ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITIES; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTITUMOR-ACTIVITY; DERIVATIVES; ACETAZOLAMIDE; DESIGN;

D O I：

10.1016/j.ejmech.2014.12.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Despite a significant work on thiadiazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects. This review throws light on the detailed synthetic approaches which have been used for the synthesis of thiadiazoles. This has been followed by the in depth analysis of the thiadiazoles with respect to their medicinal significance. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：156 / 177

页数：22

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