Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris

被引：21

作者：

Hu, Bin-Yuan ^{[1
]}

Zhao, Yun-Li ^{[1
,2
]}

Xiong, Deng-Sen ^{[1
]}

He, Ying-Jie ^{[1
]}

Zhou, Zhong-Shun ^{[1
]}

Zhu, Pei-Feng ^{[2
]}

Wang, Zhao-Jie ^{[1
]}

Wang, Yong-Liang ^{[1
]}

Zhao, Li-Xing ^{[1
]}

Luo, Xiao-Dong ^{[1
,2
]}

机构：

[1] Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 11期

关键词：

PERSPECTIVE; SKELETONS;

D O I：

10.1021/acs.orglett.1c01102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris. Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Both compounds exhibited potent antihyperuricemic bioactivity in vitro and in vivo.

引用

页码：4158 / 4162

页数：5

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