Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

被引：30
作者：
de Sousa, Damiao P. [1 ]
Silva, Rayanne H. N. [1 ]
da Silva, Epifanio F. [2 ]
Gavioli, Elaine C. [2 ]
机构：
[1] Univ Fed Paraiba, Dept Ciencias Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Rio Grande do Norte, Dept Biofis & Farmacol, BR-59078970 Natal, RN, Brazil
来源：
MOLECULES | 2017年 / 22卷 / 08期
关键词：
oil; terpene; natural products; major depression; antidepressant; animal models; UNPREDICTABLE MILD STRESS; GUANOSINE-MONOPHOSPHATE PATHWAY; NITRIC-OXIDE NO; NEUROTROPHIC FACTOR; PERILLA-FRUTESCENS; BETA-CARYOPHYLLENE; AROMATHERAPY; INVOLVEMENT; DEPRESSION; MOOD;
D O I：
10.3390/molecules22081290
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Depression is a disease that has affected a high proportion of the world's population and people of different ages, incapacitating them from good performance at work and in social relationships, and causing emotional disorders to millions of families. Therefore, the search for new therapeutic agents is considered a priority for the discovery of more effective forms of treatment. In this review, studies of essential oils and their constituents in experimental models related to depression are discussed. The mechanisms of action of the oils and the presence of psychoactive constituents in their chemical compositions are discussed. The data in the review show the therapeutic potential of essential oils and their chemical constituents for use in depressive disorders. Advanced studies using humans are needed to confirm the antidepressant properties described in animals.
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页数：21
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共 81 条
  • [1] [Anonymous], COCHRANE DATABASE SY
  • [2] [Anonymous], 2013, Diagnostic and statistical manual of mental disorders
  • [3] Antidepressant Effect of Thymoquinone in Animal Models of Depression
    Aquib, M.
    Najmi, A. K.
    Akhtar, M.
    [J]. DRUG RESEARCH, 2015, 65 (09) : 490 - 494
  • [4] β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
    Bahi, Amine
    Al Mansouri, Shamma
    Al Memari, Elyazia
    Al Ameri, Mouza
    Nurulain, Syed M.
    Ojha, Shreesh
    [J]. PHYSIOLOGY & BEHAVIOR, 2014, 135 : 119 - 124
  • [5] New approaches to antidepressant drug discovery: beyond monoamines
    Berton, O
    Nestler, EJ
    [J]. NATURE REVIEWS NEUROSCIENCE, 2006, 7 (02) : 137 - 151
  • [6] Overview of the Role of Vanillin on Redox Status and Cancer Development
    Bezerra, Daniel Pereira
    Nascimento Soares, Anne Karine
    de Sousa, Damiao Pergentino
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
  • [7] Role of neuro-immunological factors in the pathophysiology of mood disorders
    Bhattacharya, Anindya
    Derecki, Noel C.
    Lovenberg, Timothy W.
    Drevets, Wayne C.
    [J]. PSYCHOPHARMACOLOGY, 2016, 233 (09) : 1623 - 1636
  • [8] BDNF - a key transducer of antidepressant effects
    Bjorkholm, Carl
    Monteggia, Lisa M.
    [J]. NEUROPHARMACOLOGY, 2016, 102 : 72 - 79
  • [9] Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway
    Brocardo, Patricia de Souza
    Budni, Josiane
    Lobato, Kelly Ribas
    Kaster, Manuella Pinto
    Rodrigues, Ana Lucia S.
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 598 (1-3) : 37 - 42
  • [10] Opinion -: Is mood chemistry?
    Castrén, E
    [J]. NATURE REVIEWS NEUROSCIENCE, 2005, 6 (03) : 241 - 246
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