Regulatory mechanisms in the pathways of cartilage and bone formation

被引：380
作者：
de Crombrugghe, B
Lefebvre, W
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA
[2] Cleveland Clin Fdn, Lerner Res Inst, Dept Biomed Engn, Cleveland, OH 44195 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 06期
关键词：
D O I：
10.1016/S0955-0674(00)00276-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Three transcription factors of the Sox family have essential roles in different steps of the chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is needed for osteoblast differentiation, also stimulates hypertrophic chondrocyte maturation, it links the chondrocyte and osteoblast differentiation pathways in endochondral bone formation. Signaling molecules, including Indian Hedgehog, PTHrP and FGFs, also establish essential links either between these pathways, between steps in these pathways or between signaling molecules and transcription factors, so that a more comprehensive view of endochondral bone formation is emerging.
引用
收藏
页码：721 / 727
页数：7
相关论文
共 71 条
[1]   Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites [J].
Ambrosetti, DC ;
Basilico, C ;
Dailey, L .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (11) :6321-6329
[2]   SOX9 directly regulates the type-II collagen gene [J].
Bell, DM ;
Leung, KKH ;
Wheatley, SC ;
Ng, LJ ;
Zhou, S ;
Ling, KW ;
Sham, MH ;
Koopman, P ;
Tam, PPL ;
Cheah, KSE .
NATURE GENETICS, 1997, 16 (02) :174-178
[3]   A RECURRENT MUTATION IN THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH-FACTOR RECEPTOR-3 CAUSES HYPOCHONDROPLASIA [J].
BELLUS, GA ;
MCINTOSH, I ;
SMITH, EA ;
AYLSWORTH, AS ;
KAITILA, I ;
HORTON, WA ;
GREENHAW, GA ;
HECHT, JT ;
FRANCOMANO, CA .
NATURE GENETICS, 1995, 10 (03) :357-359
[4]   Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization [J].
Bi, WM ;
Huang, WD ;
Whitworth, DJ ;
Deng, JM ;
Zhang, ZP ;
Behringer, RR ;
de Crombrugghe, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6698-6703
[5]   Sox9 is required for cartilage formation [J].
Bi, WM ;
Deng, JM ;
Zhang, ZP ;
Behringer, RR ;
de Crombrugghe, B .
NATURE GENETICS, 1999, 22 (01) :85-89
[6]   Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins [J].
Black, BL ;
Olson, EN .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :167-196
[7]   Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer [J].
Bridgewater, LC ;
Lefebvre, V ;
de Crombrugghe, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (24) :14998-15006
[8]   A Ser365→Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia [J].
Chen, L ;
Li, CL ;
Qiao, WH ;
Xu, XL ;
Deng, CX .
HUMAN MOLECULAR GENETICS, 2001, 10 (05) :457-465
[9]   Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development [J].
Chung, UI ;
Schipani, E ;
McMahon, AP ;
Kronenberg, HM .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :295-304
[10]   Large scale ENU screens in the mouse: genetics meets genomics [J].
de Angelis, MH ;
Balling, R .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 400 (1-2) :25-32
12345678