Role of protein phosphatase 5 (PP5) in mediating corticosteroid insensitivity in airway smooth muscle (ASM) cells in severe asthma

被引：0
|
作者：
Chachi, Latifa [1 ]
Abbasian, Mahnaz [1 ]
Gavrila, Adelina [1 ]
Tliba, Omar [2 ]
Brightling, Christopher [1 ]
Amrani, Yassine [1 ]
机构：
[1] Univ Leicester, Infect Immun & Infalmmat, Leicester, Leics, England
[2] Thomas Jefferson Univ, Dept Pharmaceut Sci, Philadelphia, PA 19107 USA
来源：
EUROPEAN RESPIRATORY JOURNAL | 2015年 / 46卷
关键词：
Asthma; -; mechanism; Airway smooth muscle; Immunology;
D O I：
10.1183/13993003.congress-2015.PA881
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
PA881
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma
    Chachi, L.
    Abbasian, M.
    Gavrila, A.
    Alzahrani, A.
    Tliba, O.
    Bradding, P.
    Wardlaw, A. J.
    Brightling, C.
    Amrani, Y.
    ALLERGY, 2017, 72 (01) : 126 - 136
  • [2] Corticosteroid insensitivity in airway smooth muscle cells of severe asthma and COPD: Modulation by IFN-γ
    Chang, Po-Jui
    Baker, Josephine
    Bhaysar, Pankaj K.
    Perry, Mark M.
    Chung, Kian Fan
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [3] Corticosteroid insensitivity in severe asthma: Impaired nuclear translocation of glucocorticoid receptor in airway smooth muscle cells
    Chang, Po-Jui
    Baker, Josephine
    Chung, Kian Fan
    Bhavsar, Pankaj K.
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [4] Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma
    Chang, Po-Jui
    Bhavsar, Pankaj K.
    Michaeloudes, Charalambos
    Khorasani, Nadia
    Chung, Kian Fan
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (04) : 877 - +
  • [5] Glucocorticoid Insensitivity in Asthma: The Unique Role for Airway Smooth Muscle Cells
    Ramos-Ramirez, Patricia
    Tliba, Omar
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (16)
  • [6] Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFα in airway smooth muscle (ASM) cells from patients with severe asthma
    Chachi, Latifa
    Tliba, Omar
    Gavrila, Adelina
    Brightling, Christopher
    Amrani, Yassine
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [7] Potential Role of Mast Cells in Regulating Corticosteroid Insensitivity in Severe Asthma
    Alzahrani, Abdulrahman
    Hussain, Aamir
    Alhadian, Fahad
    Hakeem, Jameel
    Douaoui, Sana
    Tliba, Omar
    Bradding, Peter
    Amrani, Yassine
    LUNG INFLAMMATION IN HEALTH AND DISEASE, VOL I, 2021, 1303 : 1 - 12
  • [8] Corticosteroid insensitivityin airway smooth muscle cells from severe asthma is dependent on stimulus and cytokine product
    Rossios, Christos
    Gibeon, David
    Chung, Klan Fan
    Adcock, Ian M.
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44
  • [9] Impaired Nuclear Translocation of the Glucocorticoid Receptor in Corticosteroid-Insensitive Airway Smooth Muscle in Severe Asthma
    Chang, Po-Jui
    Michaeloudes, Charalambos
    Zhu, Jie
    Shaikh, Nooreen
    Baker, Josephine
    Chung, Kian Fan
    Bhavsar, Pankaj K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191 (01) : 54 - 62
  • [10] Compound A (CpdA) suppressed production of corticosteroid-resistant chemokines via GR-independent mechanisms in airway smooth muscle (ASM) cells
    Gavrila, Adelina
    Chachi, Latifa
    Tliba, Omar
    Brightling, Christopher
    Amrani, Yassine
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
12345