Synthesis and characterization of an alendronate-chitosan conjugate

被引：5
|
作者：
Shao, Xiaohong [1 ]
Xu, Jiqing [1 ]
Jiao, Yanpeng [1 ]
Zhou, Changren [1 ]
机构：
[1] Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510630, Guangdong, Peoples R China
来源：
MEDICAL MATERIALS AND ENGINEERING | 2012年 / 140卷
关键词：
chitosan; alendronate; polymer-drug conjugates;
D O I：
10.4028/www.scientific.net/AMM.140.53
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and H-1 NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate,
引用
收藏
页码：53 / 57
页数：5
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