Development and validation of an analytical method for quantification of metronidazole in pharmaceutical dosage form (vaginal gel)

被引：0

作者：

Bedor, Danilo C. G. ^{[1
]}

Sobrinho, Jose L. Soares ^{[2
]}

Junior, Severino G. ^{[3
]}

Ramos, Selma V. ^{[3
]}

Lima, Adley A. N. ^{[2
]}

Neto, Pedro J. Rolim ^{[2
]}

机构：

[1] NUDFAC UFPE, BR-50740521 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Lab Tecnol Med, BR-50740521 Recife, PE, Brazil

[3] Lab Farmaceut Estado Pernambuco, BR-52171010 Recife, PE, Brazil

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2008年 / 27卷 / 02期

关键词：

development of method; metronidazole; validation;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The analytical method of spectrophotometry by UV for the assay of metronidazole vaginal gel was developed and validated following all the requirements of the regulatories agencies. N-N-dimethylformamide was used for the extraction of metronidazole from pharmaceutical form and the wavelength used was 308 rim. The developed method, in accordance with the statistical treatment of the results demonstrated being precise, accurate, selective, robust and linear, consisting a trustworthy and efficient analytical alternative with low cost for determination of metronidazole vaginal gel in the laboratorial routine.

引用

页码：263 / 265

页数：3

共 14 条

[1] Simultaneous determination of metronidazole and miconazole in pharmaceutical dosage forms by RP-HPLC [J].