Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure

被引：3
|
作者：
Mausner-Fainberg, Karin [1 ]
Penn, Moran [2 ]
Golan, Maya [1 ]
Benhamou, Moshe [1 ,2 ]
Gertel, Smadar [2 ,3 ]
Karni, Arnon [1 ,2 ,4 ]
机构：
[1] Tel Aviv Sourasky Med Ctr, Dept Neurol, Neuroimmunol Lab, Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Tel Aviv Sourasky Med Ctr, Dept Rheumatol, Tel Aviv, Israel
[4] Tel Aviv Univ, Segol Sch Neurosci, Tel Aviv, Israel
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 327卷
关键词：
Coco; Bone morphogenetic proteins; Multiple sclerosis; Oligodendrocytes precursor cells (OPCs); Oligodendrogenesis; P19; cells; IMMUNE CELLS; SPINAL-CORD; STEM-CELLS; TGF-BETA; PROTEINS; DIFFERENTIATION; BMP; REMYELINATION; LESIONS; FAMILY;
D O I：
10.1016/j.jneuroim.2019.01.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Demyelination, axonal loss and failure of tissue repair characterize MS lesions. Bone morphogenetic proteins (BMPs) signaling is associated with remyelination failure. Coco is one of the BMP antagonists. We found reduced Coco serum levels in relapsing-remitting MS (RR-MS) and primary progressive MS (PP-MS) patients compared to matched healthy controls (HC) and patients with rheumatoid arthritis. Exposure of P19 cells, in the presence of retinoic acid, BMP-2, or BMP-4 to Coco, at average sera level of MS patients failed to induce neuronal phenotype, in contrast to the average sera level of HC. Coco may be a player in the BMP dysregulation and the tissue repair failure in MS.
引用
收藏
页码：36 / 40
页数：5
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