The microbiome in spondyloarthritis

被引：28

作者：

Breban, Maxime ^{[1
,2
,3
]}

Beaufrere, Marie ^{[1
,2
,3
]}

Glatigny, Simon ^{[1
,3
]}

机构：

[1] Univ Paris Saclay, UVSQ, INSERM, Infect & Inflammat,UMR 1173, 2 Ave Source Bievre, F-78180 Montigny Le Bretonneux, France

[2] Hop Ambroise Pare, AP HP, Serv Rhumatol, 9 Ave Charles de Gaulle, F-92100 Boulogne, France

[3] Univ Paris 05, Lab Excellence Inflamex, Sorbonne Paris Cite, Paris, France

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2019年 / 33卷 / 06期

关键词：

Ankylosing spondylitis; Spondyloarthritis; Reactive arthritis; Microbiota; HLA-B27; Animal models; HLA-B27 TRANSGENIC RATS; ANKYLOSING-SPONDYLITIS; INFLAMMATORY DISEASE; REACTIVE ARTHRITIS; AXIAL SPONDYLOARTHRITIS; KLEBSIELLA-PNEUMONIAE; INTESTINAL DYSBIOSIS; COMMENSAL BACTERIA; GUT INFLAMMATION; CHRONIC COLITIS;

D O I：

10.1016/j.berh.2020.101495

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A causal link between the wealth of microbes that populate our body surfaces, designated as microbiota, and inflammatory disorders, including ankylosing spondylitis and the related spondyloarthritis (SpA) has been suspected for decades. This specially concerns the gut microbiota that became only recently accessible to thorough description thanks to massive sequencing methods or metagenomics. Here, we review evidences supporting the existence of microbiota imbalance or dysbiosis in the context of SpA. We also discuss currently existing evidences for a causal relationship between such dysbiosis and disease development, as well as putative therapeutic implications. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：17

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