Cardiomyocyte-transistor-hybrids for sensor application

被引：85

作者：

Ingebrandt, S

Yeung, CK

Krause, M

Offenhäusser, A

机构：

[1] Forschungszentrum Julich, Inst Thin Films & Interfaces ISG2, D-52425 Julich, Germany

[2] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

BIOSENSORS & BIOELECTRONICS | 2001年 / 16卷 / 7-8期

关键词：

field effect transistors; extracellular recording; dissociated cardiac myocytes; pharmacological biosensor;

D O I：

10.1016/S0956-5663(01)00170-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

An extracellular recording system has been designed for the detection of electrical cell signals using p-channel or n-channel field-effect transistor (FET) arrays with non-metallized gates. Signals from rat heart muscle cell were recorded by these devices and the results described on the basis of an equivalent circuit. This technique is sensitive enough to detect minute changes of the extracellular membrane voltage and has potential applications in drug screening. We show that known cardiac stimulants (isoproterenol, norepinephrine) and relaxants (verapamil, carbamylcholine) have characteristic effects on the heart cells in terms of the changes of beat frequencies in the absence or presence of corresponding agents. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：565 / 570

页数：6

共 18 条

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