Brain volume and magnetic susceptibility differences in children and adolescents with prenatal alcohol exposure

被引:4
作者
Nakhid, Daphne [1 ,2 ,3 ]
McMorris, Carly [2 ,3 ,4 ,5 ]
Sun, Hongfu [6 ]
Gibbard, William Benton [2 ,5 ]
Tortorelli, Christina [7 ]
Lebel, Catherine [2 ,3 ,8 ]
机构
[1] Univ Calgary, Dept Neurosci, Calgary, AB, Canada
[2] Univ Calgary, Alberta Childrens Hosp Res Inst ACHRI, Calgary, AB, Canada
[3] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada
[4] Univ Calgary, Sch & Appl Child Psychol, Werklund Sch Educ, Calgary, AB, Canada
[5] Univ Calgary, Dept Pediat, Calgary, AB, Canada
[6] Univ Queensland, Sch Informat Technol & Elect Engn, Brisbane, Qld, Australia
[7] Mt Royal Univ, Dept Child Studies & Social Work, Calgary, AB, Canada
[8] Univ Calgary, Dept Radiol, Calgary, AB, Canada
来源
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH | 2022年 / 46卷 / 10期
基金
加拿大自然科学与工程研究理事会;
关键词
brain; fetal alcohol spectrum disorder; iron; prenatal alcohol exposure; quantitative susceptibility mapping; IRON-DEFICIENCY ANEMIA; BASAL GANGLIA; MAPPING QSM; RAT MODEL; HIPPOCAMPAL; DISORDER; DYSMORPHOLOGY; VALIDATION; REDUCTIONS; RESONANCE;
D O I
10.1111/acer.14928
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background Prenatal alcohol exposure (PAE) can negatively affect brain development thereby increasing the risk of cognitive deficits, behavioral challenges, and mental health problems. Brain iron is important for a number of physiological processes for healthy brain development. Animal studies show that PAE reduced brain iron; however, this has not been investigated in human children with PAE. Methods We studied 20 children and adolescents with PAE and 44 unexposed children and adolescents aged 7.5 to 15 years. All children underwent quantitative susceptibility mapping and T1-weighted magnetic resonance imaging scans. Susceptibility and volume measurements of the caudate, putamen, pallidum, thalamus, amygdala, hippocampus, and nucleus accumbens were extracted using FreeSurfer. ANCOVAs were used to compare volume and susceptibility between groups for each region of interest, controlling for age and gender. For structures where susceptibility differed by group, we also tested for an association between intelligence quotient (IQ) and susceptibility. Results There were no significant group differences in susceptibility after multiple comparison correction, though the PAE group had higher susceptibility in the thalamus compared to unexposed participants before correction (p = 0.032, q = 0.230). There was no association between IQ and thalamus susceptibility. The PAE group had significantly lower volume in the bilateral caudate, bilateral pallidum, and left putamen. Conclusions These findings suggest susceptibility may be altered in children and adolescents with PAE, though more research is needed. Volume reductions are consistent with previous literature and likely underlie cognitive and behavioral deficits associated with PAE.
引用
收藏
页码:1797 / 1807
页数:11
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