Exploring autonomic nervous system dysfunction in patients with cancer cachexia: A pilot study

被引：16

作者：

Chauhan, Alpna

Sequeria, Ashika

Manderson, Cathann

Maddocks, Matthew

Wasley, David ^{[2
]}

Wilcock, Andrew ^{[1
]}

机构：

[1] Nottingham Univ Hosp NHS Trust, Hayward House Macmillan Specialist Palliat Care U, Nottingham, England

[2] Univ Wales Inst, Cardiff Sch Sport, Cardiff, S Glam, Wales

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2012年 / 166卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Cancer cachexia; Heart rate variability; Autonomic nervous system;

D O I：

10.1016/j.autneu.2011.09.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Introduction: Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia. Methods: In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines. Results: Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms(2) 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P<0.05). Biochemical values did not differ. Conclusion: Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：93 / 95

页数：3

共 9 条

[1] Neurohumoral activation as a link to systemic manifestations of chronic lung disease [J].