Fabrication of magnetite nano particles and modification with metal organic framework of Zn2+ for sorption of doxycyline

被引:16
|
作者
Nooreini, Mahsa Ghassemi [1 ]
Panahi, Homayon Ahmad [2 ]
机构
[1] Islamic Azad Univ, Karaj Branch, Dept Chem, Karaj, Iran
[2] Islamic Azad Univ, Cent Tehran Branch, Dept Chem, Tehran, Iran
关键词
Doxycycline; Drug delivery; Metal organic framework; Magnetic nano particles; Modification; DRUG-DELIVERY; FE3O4; NANOPARTICLES; CORE-SHELL; HPLC METHOD; DOXYCYCLINE; ASSAY; MICROSPHERES; DEGRADATION; ADSORPTION; SAMPLES;
D O I
10.1016/j.ijpharm.2016.08.021
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study presents a novel method for synthesis and characterization of a metal-organic framework and application in drug delivery. The first step was synthesis of amino functionalized magnetite that was then modified by a metal-organic framework of Zn2+. This newly developed nano-sorbent was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive x-ray spectroscopy, thermogravimetric analysis, vibrating sample magnetometer and x-ray diffraction. Doxycycline was loaded to the nano-sorbent and effects of the variable parameters, kinetics of adsorption, release and capacity of adsorption were investigated. Test results specified maximum sorption of 21.5 mg g(-1) for doxycycline in conditions of nano-sorbent at pH 7 and optimum time of 10 min. Equilibrium adsorption data were analyzed by the Langmuir, Freundlich and Temkin models. Results showed that about 40% of doxycycline was released in simulated gastric fluid for the 30 min and more than 70% was released in simulated intestinal fluid during 12 h. These results were satisfactory and demonstrate that this new nano-sorbent modified with metal-organic framework had a good level of efficiency for drug delivery of doxycycline. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:178 / 185
页数:8
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