Carbapenem resistance among Escherichia coli and Klebsiella pneumoniae in a tertiary care hospital in south India

被引：44
作者：
Nagaraj, S. [2 ]
Chandran, S. P. [1 ,2 ]
Shamanna, P. [2 ]
Macaden, R. [1 ]
机构：
[1] St Johns Res Inst, Infect Dis Unit, Bangalore 560034, Karnataka, India
[2] St Johns Med Coll, Dept Microbiol, Bangalore 560034, Karnataka, India
来源：
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY | 2012年 / 30卷 / 01期
关键词：
Antibiotic resistance; carbapenemases; New Delhi metallo-beta-lactamase; BETA; THREAT;
D O I：
10.4103/0255-0857.93054
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Carbapenem resistance among clinical isolates of Enterobacteriaceae, especially Escherichia coli and Klebsiella pneumoniae, is largely conferred by metallo-beta-lactamase (MBL). Fifty-one non repetitive isolates of carbapenem-resistant (Meropenem and Imipenem) E. coli and K. pneumoniae were studied to determine the molecular mechanism for resistance. Presence of bla(NDM) and bla(VIM) was determined by polymerase chain reaction (PCR) and DNA sequencing. bla(NDM) was detected from majority of carbapenem-resistant K. pneumoniae (75%) and E. coli (66.6%). Timely detection and appropriate and aggressive infection control measures are required to control the spread of these bacteria in healthcare settings.
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页码：93 / 95
页数：3
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