Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia

被引：7
|
作者：
Lee, Chia-Lin [1 ,2 ]
Yen, Ming-Hon [3 ]
Hwang, Tsong-Long [4 ,5 ,6 ,7 ]
Yang, Juan-Cheng [2 ,8 ]
Peng, Chieh-Yu [2 ,8 ]
Chen, Chao-Jung [9 ,10 ]
Chang, Wen-Yi [4 ,5 ,6 ,7 ]
Wu, Yang-Chang [2 ,8 ,11 ,12 ]
机构：
[1] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan
[2] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan
[3] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 80708, Taiwan
[4] Chang Gung Univ, Coll Med, Healthy Aging Res Ctr, Sch Tradit Med,Grad Inst Nat Prod, Taoyuan 33302, Taiwan
[5] Chang Gung Univ, Healthy Aging Res Ctr, Chinese Herbal Med Res Team, Taoyuan 33302, Taiwan
[6] Chang Gung Univ Sci & Technol, Dept Cosmet Sci, Taoyuan 33302, Taiwan
[7] Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Taoyuan 33302, Taiwan
[8] China Med Univ, Coll Pharm, Sch Pharm, Taichung 40402, Taiwan
[9] China Med Univ, Grad Inst Integrated Med, Taichung 40402, Taiwan
[10] China Med Univ Hosp, Dept Med Res, Prote Core Lab, Taichung 40447, Taiwan
[11] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan
[12] China Med Univ Hosp, Ctr Mol Med, Taichung 40402, Taiwan
来源：
PHYTOCHEMISTRY LETTERS | 2015年 / 12卷
关键词：
Dichrocephala integrifolia; Asteraceae; Anti-inflammatory effect; Cytotoxicity; DITERPENES; SESQUITERPENES;
D O I：
10.1016/j.phytol.2015.04.012
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Portulide glucoside A (1), 14-acetoxy-9-epi-britanlin A (2), and dichroditerpene A (3) along with eight known compounds were isolated from Dichrocephala integrifolia. Diterpenoids 3 and 5 showed antineutrophilic inflammatory activities against not only superoxide anion generation with IC50 values of 1.74 and 4.40 mu M, but also elastase release with IC50 values of 1.32 and 3.67 mu M, respectively. Additionally, sinapyl alcohols 8 and 9 showed moderate cytotoxicity toward DU145 human prostate cancer cell line with IC50 values of 24.1 and 19.0 mu M, respectively. Isolates 1-10 were found for the first time in this plant. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：237 / 242
页数：6
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