Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes

被引：34
作者：
Simpson, Melissa [1 ]
Snell-Bergeon, Janet K. [1 ]
Kinney, Gregory L. [1 ]
Lache, Orit [2 ]
Miller-Lotan, Rachel [2 ]
Anbinder, Yefim [2 ]
Rewers, Marian J. [1 ]
Levy, Andrew P. [2 ]
机构：
[1] Barbara Davis Ctr Childhood Diabet, Aurora, CO USA
[2] Technion Israel Inst Technol, Technion Fac Med, Haifa, Israel
来源：
CARDIOVASCULAR DIABETOLOGY | 2011年 / 10卷
关键词：
Cardiovascular disease; type 1 diabetes mellitus; coronary artery calcium; hyperglycemia; genetics; Haptoglobin; ULTRAFAST COMPUTED-TOMOGRAPHY; MYOCARDIAL-INFARCTION; VASCULAR COMPLICATIONS; CARDIOVASCULAR-DISEASE; EVOLUTIONARY PRODUCT; POINT MUTATION; INDIVIDUALS; CALCIUM; MELLITUS; POLYMORPHISM;
D O I：
10.1186/1475-2840-10-99
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis. Methods: CAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects participating in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. Hp typing was performed on plasma samples by polyacrylamide gel electrophoresis. Results: The Hp 2-2 genotype predicted development of significant CAC only in subjects with diabetes who were free of CAC at baseline (OR: 1.95, 95% CI: 1.07-3.56, p = 0.03), compared to those without the Hp 2-2 genotype, controlling for age, sex, blood pressure and HDL-cholesterol. Hp 2 appeared to have an allele-dose effect on development of CAC. Hp genotype did not predict CAC progression in individuals without diabetes. Conclusions: Hp genotype may aid prediction of accelerated coronary atherosclerosis in subjects with type 1 diabetes.
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页数：7
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