Adjuvant Therapy for Cutaneous Melanoma

被引:1
作者
Schuitevoerder, Darryl [1 ]
Vining, Charles C. [1 ]
Tseng, Jennifer [1 ]
机构
[1] Univ Chicago, Dept Surg, 5841 South Maryland Ave MC5094, Chicago, IL 60637 USA
关键词
Melanoma; Adjuvant therapy; Immunotherapy; Targeted therapy; BRAF; MEK; DABRAFENIB PLUS TRAMETINIB; RANDOMIZED PHASE-III; HIGH-RISK MELANOMA; ADVANCED BRAF(V600)-MUTANT MELANOMA; HIGH-DOSE INTERFERON-ALPHA-2B; COOPERATIVE-ONCOLOGY-GROUP; LYMPH-NODE DISSECTION; RESECTED STAGE-III; METASTATIC MELANOMA; OPEN-LABEL;
D O I
10.1016/j.soc.2020.02.009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This article presents the current data supporting adjuvant therapy for patients with cutaneous melanoma. With the recent development of novel immunotherapy agents as well as targeted therapy, there are strong data to support the use of these therapies in patients at high risk of developing recurrent or metastatic disease.
引用
收藏
页码:455 / +
页数:12
相关论文
共 64 条
[41]   Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma [J].
Long, G. V. ;
Hauschild, A. ;
Santinami, M. ;
Atkinson, V. ;
Mandala, M. ;
Chiarion-Sileni, V. ;
Larkin, J. ;
Nyakas, M. ;
Dutriaux, C. ;
Haydon, A. ;
Robert, C. ;
Mortier, L. ;
Schachter, J. ;
Schadendorf, D. ;
Lesimple, T. ;
Plummer, R. ;
Ji, R. ;
Zhang, P. ;
Mookerjee, B. ;
Legos, J. ;
Kefford, R. ;
Dummer, R. ;
Kirkwood, J. M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (19) :1813-1823
[42]   Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study [J].
Long, G. V. ;
Flaherty, K. T. ;
Stroyakovskiy, D. ;
Gogas, H. ;
Levchenko, E. ;
de Braud, F. ;
Larkin, J. ;
Garbe, C. ;
Jouary, T. ;
Hauschild, A. ;
Chiarion-Sileni, V. ;
Lebbe, C. ;
Mandala, M. ;
Millward, M. ;
Arance, A. ;
Bondarenko, I. ;
Haanen, J. B. A. G. ;
Hansson, J. ;
Utikal, J. ;
Ferraresi, V. ;
Mohr, P. ;
Probachai, V. ;
Schadendorf, D. ;
Nathan, P. ;
Robert, C. ;
Ribas, A. ;
Davies, M. A. ;
Lane, S. R. ;
Legos, J. J. ;
Mookerjee, B. ;
Grob, J. -J. .
ANNALS OF ONCOLOGY, 2017, 28 (07) :1631-1639
[43]   Long-Term Outcomes in Patients With BRAF V600-Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib [J].
Long, Georgina, V ;
Eroglu, Zeynep ;
Infante, Jeffrey ;
Patel, Sapna ;
Daud, Adil ;
Johnson, Douglas B. ;
Gonzalez, Rene ;
Kefford, Richard ;
Hamid, Omid ;
Schuchter, Lynn ;
Cebon, Jonathan ;
Sharfman, William ;
McWilliams, Robert ;
Sznol, Mario ;
Redhu, Suman ;
Gasal, Eduard ;
Mookerjee, Bijoyesh ;
Weber, Jeffrey ;
Flaherty, Keith T. .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (07) :667-+
[44]   Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma [J].
Long, Georgina V. ;
Menzies, Alexander M. ;
Nagrial, Adnan M. ;
Haydu, Lauren E. ;
Hamilton, Anne L. ;
Mann, Graham J. ;
Hughes, T. Michael ;
Thompson, John F. ;
Scolyer, Richard A. ;
Kefford, Richard F. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (10) :1239-1246
[45]   Adjuvant vemurafenib in resected, BRAFV600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial [J].
Maio, Michele ;
Lewis, Karl ;
Demidov, Lev ;
Mandala, Mario ;
Bondarenko, Igor ;
Ascierto, Paolo A. ;
Herbert, Christopher ;
Mackiewicz, Andrzej ;
Rutkowski, Piotr ;
Guminski, Alexander ;
Goodman, Grant R. ;
Simmons, Brian ;
Ye, Chenglin ;
Yan, Yibing ;
Schadendorf, Dirk .
LANCET ONCOLOGY, 2018, 19 (04) :510-520
[46]   Final Results of the Sunbelt Melanoma Trial: A Multi-Institutional Prospective Randomized Phase III Study Evaluating the Role of Adjuvant High-Dose Interferon Alfa-2b and Completion Lymph Node Dissection for Patients Staged by Sentinel Lymph Node Biopsy [J].
McMasters, Kelly M. ;
Egger, Michael E. ;
Edwards, Michael J. ;
Ross, Merrick I. ;
Reintgen, Douglas S. ;
Noyes, R. Dirk ;
Martin, Robert C. G., II ;
Goydos, James S. ;
Beitsch, Peter D. ;
Urist, Marshall M. ;
Ariyan, Stephan ;
Sussman, Jeffrey J. ;
Davidson, B. Scott ;
Gershenwald, Jeffrey E. ;
Hagendoorn, Lee J. ;
Stromberg, Arnold J. ;
Scoggins, Charles R. .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) :1079-+
[47]   Interferon Alpha Adjuvant Therapy in Patients With High-Risk Melanoma: A Systematic Review and Meta-analysis [J].
Mocellin, Simone ;
Pasquali, Sandro ;
Rossi, Carlo R. ;
Nitti, Donato .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (07) :493-501
[48]   Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma [J].
Morton, D. L. ;
Thompson, J. F. ;
Cochran, A. J. ;
Mozzillo, N. ;
Nieweg, O. E. ;
Roses, D. F. ;
Hoekstra, H. J. ;
Karakousis, C. P. ;
Puleo, C. A. ;
Coventry, B. J. ;
Kashani-Sabet, M. ;
Smithers, B. M. ;
Paul, E. ;
Kraybill, W. G. ;
McKinnon, J. G. ;
Wang, H. -J. ;
Elashoff, R. ;
Faries, M. B. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (07) :599-609
[49]  
Muthusamy VPT, 2011, SKIN CANC RISK FACTO, P87
[50]  
National Comprehensive Cancer Network, 2019, CUTANEOUS MELANOMA