Selectivity in multiple multicomponent reactions: types and synthetic applications

被引：45
作者：
Ghashghaei, Ouldouz [1 ,2 ]
Seghetti, Francesca [3 ]
Lavilla, Rodolfo [1 ,2 ]
机构：
[1] Univ Barcelona, Lab Med Chem, Fac Pharm & Food Sci, Av Joan 23,27-31, E-08028 Barcelona, Spain
[2] Univ Barcelona, Inst Biomed IBUB, Av Joan 23,27-31, E-08028 Barcelona, Spain
[3] Univ Bologna, Dept Pharm & Biotechnol FaBiT, Via Belmeloro 6, I-40126 Bologna, Italy
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 15卷
关键词：
isocyanides; multicomponent reactions; reaction discovery; selectivity; BUILDING-BLOCKS; UGI REACTIONS; MACROCYCLIZATIONS; LIBRARY; ACID; POLYMERIZATION; ISOCYANIDES; PHASE; UNION; CAGES;
D O I：
10.3762/bjoc.15.46
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Multiple multicomponent reactions reach an unparalleled level of connectivity, leading to highly complex adducts. Usually, only one type of transformation involving the same set of reactants takes place. However, in some occasions this is not the case. Selectivity issues then arise, and different scenarios are analyzed. The structural pattern of the reactants, the reaction design and the experimental conditions are the critical factors dictating selectivity in these processes.
引用
收藏
页码：521 / 534
页数：14
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