Emerging roles of JMJD3 in cancer

被引：11

作者：

Farzaneh, Maryam ^{[1
,2
]}

Kuchaki, Zeinab ^{[3
]}

Rashid Sheykhahmad, Fatima ^{[4
]}

Meybodi, Seyed Mohammadmahdi ^{[5
]}

Abbasi, Yusef ^{[6
]}

Gholami, Effat ^{[7
]}

Ghaedrahmati, Farhoodeh ^{[8
]}

Anbiayee, Omid ^{[9
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Fertil Infertil & Perinatol Res Ctr, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Cellular & Mol Res Ctr, Ahvaz, Iran

[3] Shahed Univ, Fac Nursing & Midwifery, Dept Nursing, Tehran, Iran

[4] Ardabil Univ Med Sci, Sch Med, Dept Internal Med, Ardebil, Iran

[5] Islamic Azad Univ, Tabriz Branch, Dept Vet Med, Tabriz, Iran

[6] Arak Univ Med Sci, Dept Anat, Fac Med, Arak, Iran

[7] Univ Barcelona, Sect Zool & Biol Anthropol, Fac Biol, Dept Evolutionary Biol Ecol & Environm Sci, Barcelona, Spain

[8] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[9] Shiraz Univ Med Sci, Sch Med, Nemazi Hosp, Cardiovasc Res Ctr, Shiraz, Iran

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2022年 / 24卷 / 07期

关键词：

JMJD3; Epigenome; Metastasis; Invasion; Cancer; HISTONE DEMETHYLASE JMJD3; NF-KAPPA-B; PROGNOSTIC-SIGNIFICANCE; CELLULAR SENESCENCE; INHIBITOR GSK-J4; GENE-EXPRESSION; DOWN-REGULATION; KDM6B; H3K27ME3; LUNG;

D O I：

10.1007/s12094-021-02773-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Histone lysine methylation plays a key role in gene activation and repression. The trimethylation of histone H3 on lysine-27 (H3K27me3) is a critical epigenetic event that is controlled by Jumonji domain-containing protein-3 (JMJD3). JMJD3 is a histone demethylase that specifically removes methyl groups. Previous studies have suggested that JMJD3 has a dual role in cancer cells. JMJD3 stimulates the expression of proliferative-related genes and increases tumor cell growth, propagation, and migration in various cancers, including neural, prostate, ovary, skin, esophagus, leukemia, hepatic, head and neck, renal, lymphoma, and lung. In contrast, JMJD3 can suppress the propagation of tumor cells, and enhance their apoptosis in colorectal, breast, and pancreatic cancers. In this review, we summarized the recent advances of JMJD3 function in cancer cells.

引用

页码：1238 / 1249

页数：12

共 139 条

[1] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [J].