Optimizing treatments for anxiety by age and genetics

被引：14

作者：

Casey, B. J. ^{[1
]}

Lee, Francis S. ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Sackler Inst Dev Psychobiol, Dept Psychiat, New York, NY 10065 USA

来源：

AFFECTIVE DISORDERS AND TRAUMATIC BRAIN INJURY | 2015年 / 1345卷

关键词：

COGNITIVE-BEHAVIORAL THERAPY; BDNF VAL66MET; NEUROTROPHIC FACTOR; PREFRONTAL CORTEX; FEAR EXTINCTION; HUMAN AMYGDALA; D-CYCLOSERINE; MEMORY TRACE; RECONSOLIDATION; HUMANS;

D O I：

10.1111/nyas.12746

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This paper highlights recent human neuroimaging and cross-species developmental and genetic studies that examine how fear regulation varies by age and the individual, especially during the period of adolescence, when there is a peak in the prevalence of anxiety disorders. The findings have significant implications for understanding who may be at risk for anxiety disorders and for whom, and when, an exposure-based therapy may be most effective. We provide proof of concept for targeting treatment to the individual as a function of age and genetics, inferred from mouse and human studies, and suggest optimization of treatment for nonresponders.

引用

页码：16 / 24

页数：9

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