Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

被引：27

作者：

Fabbiani, Massimiliano ^{[2
]}

Di Giambenedetto, Simona ^{[2
]}

Sali, Michela ^{[1
]}

Farina, Salvatore ^{[2
]}

Sansonetti, Paola ^{[1
,3
]}

Tamburrini, Enrica ^{[2
]}

Dal Verme, Lorenzo Zileri ^{[4
]}

Deogu, Giovanni ^{[1
]}

De Luca, Andrea ^{[2
,5
]}

Kelvin, David ^{[3
]}

Cauda, Roberto ^{[2
]}

Fadda, Giovanni ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Microbiol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy

[3] Univ Hlth Network, Div Expt Therapeut, Toronto, ON, Canada

[4] Univ Cattolica Sacro Cuore, Dept Emergency Med, I-00168 Rome, Italy

[5] Siena Univ Hosp, Infect Dis Unit, Siena, Italy

来源：

VACCINE | 2011年 / 29卷 / 16期

关键词：

HIV; Influenza A (H1N1); Swine flu; Vaccination; Immunogenicity; ANTIBODY-RESPONSES; H1N1;

D O I：

10.1016/j.vaccine.2011.02.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 > 200 cells/mu L while individuals with CD4 < 200 cells/mu L showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2836 / 2839

页数：4

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