Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients

被引：27
|
作者：
Fabbiani, Massimiliano [2 ]
Di Giambenedetto, Simona [2 ]
Sali, Michela [1 ]
Farina, Salvatore [2 ]
Sansonetti, Paola [1 ,3 ]
Tamburrini, Enrica [2 ]
Dal Verme, Lorenzo Zileri [4 ]
Deogu, Giovanni [1 ]
De Luca, Andrea [2 ,5 ]
Kelvin, David [3 ]
Cauda, Roberto [2 ]
Fadda, Giovanni [1 ]
机构：
[1] Univ Cattolica Sacro Cuore, Inst Microbiol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy
[3] Univ Hlth Network, Div Expt Therapeut, Toronto, ON, Canada
[4] Univ Cattolica Sacro Cuore, Dept Emergency Med, I-00168 Rome, Italy
[5] Siena Univ Hosp, Infect Dis Unit, Siena, Italy
来源：
VACCINE | 2011年 / 29卷 / 16期
关键词：
HIV; Influenza A (H1N1); Swine flu; Vaccination; Immunogenicity; ANTIBODY-RESPONSES; H1N1;
D O I：
10.1016/j.vaccine.2011.02.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 > 200 cells/mu L while individuals with CD4 < 200 cells/mu L showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2836 / 2839
页数：4
相关论文
共 50 条
  • [1] Trial of 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine.
    Clark, Tristan W.
    Pareek, Manish
    Hoschler, Katja
    Dillon, Helen
    Nicholson, Karl G.
    Groth, Nicola
    Stephenson, Iain
    NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (25): : 2424 - 2435
  • [2] Immunogenicity, safety and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with β-thalassemia major
    Esposito, Susanna
    D'Angelo, Emanuela
    Daleno, Cristina
    Peia, Francesco
    Scala, Alessia
    Serra, Domenico
    Mirra, Nadia
    Galeone, Carlotta
    Principi, Nicola
    VACCINE, 2010, 28 (50) : 7825 - 7828
  • [3] Safety and immunogenicity of a monovalent MF59®-adjuvanted A/H1N1 vaccine in HIV-infected children and young adults
    Palma, Paolo
    Romiti, Maria Luisa
    Bernardi, Stefania
    Pontrelli, Giuseppe
    Mora, Nadia
    Santilli, Veronica
    Tchidjou, Hyppolite Kuekou
    Aquilani, Angela
    Cotugno, Nicola
    Alghisi, Federico
    Lucidi, Vincenzina
    Rossi, Paolo
    Douagi, Iyadh
    BIOLOGICALS, 2012, 40 (02) : 134 - 139
  • [4] Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis
    Alghisi, Federico
    Palma, Paolo
    Montemitro, Enza
    Bernardi, Stefania
    Pontrelli, Giuseppe
    Rossi, Paolo
    Lucidi, Vincenzina
    THORAX, 2011, 66 (03) : 259 - 260
  • [5] Immune response to influenza A(H1N1)v in HIV-infected patients
    Sansonetti, Paola
    Sali, Michela
    Fabbiani, Massimiliano
    Morandi, Matteo
    Martucci, Rosa
    Danesh, Ali
    Delogu, Giovanni
    Bermejo-Martin, Jesus F.
    Sanguinetti, Maurizio
    Kelvin, David
    Cauda, Roberto
    Fadda, Giovanni
    Rubino, Salvatore
    JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2014, 8 (01): : 101 - 109
  • [6] Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study
    Heikkinen, Terho
    Young, James
    van Beek, Erik
    Franke, Henk
    Verstraeten, Thomas
    Weil, John G.
    Della Cioppa, Giovanni
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2012, 207 (03)
  • [7] Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals
    Kajaste-Rudnitski, Anna
    Galli, Laura
    Nozza, Silvia
    Tambussi, Giuseppe
    Di Pietro, Andrea
    Pellicciotta, Gabriele
    Monti, Alessandro
    Mascagni, Paolo
    Moro, Matteo
    Vicenzi, Elisa
    AIDS, 2011, 25 (02) : 177 - 183
  • [8] Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients
    Son, Jungmin
    Lee, Soo Bong
    Lee, Dong Won
    Kim, Il Young
    Lee, Su Jin
    Lee, Sun Min
    Song, Sang Heon
    Seong, Eun Young
    Kwak, Ihm Soo
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2013, 17 (02) : 275 - 283
  • [9] Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients
    Jungmin Son
    Soo Bong Lee
    Dong Won Lee
    Il Young Kim
    Su Jin Lee
    Sun Min Lee
    Sang Heon Song
    Eun Young Seong
    Ihm Soo Kwak
    Clinical and Experimental Nephrology, 2013, 17 : 275 - 283
  • [10] Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature
    Ruiz-Aragon, J.
    Grande Tejada, A. M.
    Marquez-Pelaez, S.
    Molina Linde, J. M.
    Yang, R.
    ANALES DE PEDIATRIA, 2013, 79 (04): : 208 - 217
12345