Prognostic value of PD-L1 expression combined with hypoxia-associated immunosuppression in hepatocellular carcinoma

被引:1
作者
Qian, Yanyan [1 ]
Su, Hongmeng [1 ]
Ge, Yanping [1 ]
Lei, Kai [2 ]
Li, Yiping [3 ]
Fan, Hong [1 ]
机构
[1] Southeast Univ, Med Sch, Dept Med Genet & Dev Biol, Key Lab Dev Genes & Human Dis,Minist Educ, Nanjing 210009, Jiangsu, Peoples R China
[2] Southeast Univ, Med Sch, Nanjing 210009, Jiangsu, Peoples R China
[3] Southeast Univ, Med Sch, Dept Pathol, Nanjing 210009, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
CD68(+) macrophages; CD8(+) T cells; HCC; HIF-1; alpha; PD-L1; prognosis; TUMOR MICROENVIRONMENT; INDUCIBLE FACTORS; CELL CARCINOMA; CANCER; SORAFENIB; BLOCKADE; ANGIOGENESIS; LYMPHOCYTE; REGULATORS; IMPACT;
D O I
10.2217/bmm-2021-1051
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Hypoxia and immunosuppression are two properties of cancer. This study intends to establish the potential relationship between these two hallmarks in hepatocellular carcinoma (HCC). Materials & methods: A bioinformatics analysis of data obtained from the Cancer Genome Atlas and a retrospective single-center analysis based on a tissue microarray were utilized in this study. Results: We identified a hypoxia-high subtype of patients with immunosuppressive HCC which represented a poor prognosis in the Cancer Genome Atlas cohort. Immunohistochemical analysis of the tissue microarray showed that tumor PD-L1 expression was positively linked to HIF-1 alpha expression, pro-tumor immunocyte infiltration and poor survival in HCC patients. Conclusion: This study provides evidence supporting the correlation between hypoxic signals and immunosuppression in HCC; the combined use of them might improve survival prediction and act as a potential predictor for PD-1/PD-L1 therapy.
引用
收藏
页码:435 / 448
页数:14
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