Pd-catalyzed carboetherification of β,γ-unsaturated oximes:: A novel approach to Δ2-isoxazolines

被引：88

作者：

Jiang, Dahong ^{[1
,2
]}

Peng, Jinsong ^{[3
]}

Chen, Yuanwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] NE Forestry Univ, Coll Sci, Haerbin 150040, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 09期

关键词：

D O I：

10.1021/ol8002173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route to the synthesis of Delta(2)-isoxazoline derivatives is described. Reaction of beta,gamma-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted Delta(2)-isoxazolines in good yields. The use of Xantphos as ligand is crucial for the transformation. The carboetherification products can be further converted to beta-hydroxy ketones in the presence of Fe powder and NH(4)Cl.

引用

页码：1695 / 1698

页数：4

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