A molecular arms race: new insights into anti-CRISPR mechanisms

被引：5

作者：

Mallon, John ^{[1
]}

Bailey, Scott ^{[1
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21218 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 09期

关键词：

IMMUNE-SYSTEM; DNA; DEGRADATION; CASCADE; CAS3; INTERFERENCE; ACQUISITION; PROKARYOTES;

D O I：

10.1038/nsmb.3287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacteria and phages are engaged in a molecular arms race, constantly coevolving to best each other. The crystal structure of the anti-CRISPR protein AcrF3 bound to Cas3, an essential component of CRISPR-based immunity, sheds light on how phages have found ways to suppress bacterial immunity.

引用

页码：765 / 766

页数：2

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