Vesicular Carriers for Skin Drug Delivery: The Pheroid™ Technology

被引：7
作者：
Kilian, Dewald [1 ]
Shahzad, Yasser [1 ]
Fox, Lizelle [1 ]
Gerber, Minja [1 ]
Du Plessis, Jeanetta [1 ]
机构：
[1] North West Univ, Fac Hlth Sci, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa
来源：
CURRENT PHARMACEUTICAL DESIGN | 2015年 / 21卷 / 20期
基金：
新加坡国家研究基金会;
关键词：
Elasticity; permeability; pheroid (TM); skin; mechanism of action; transdermal; vesicular carriers; HUMAN STRATUM-CORNEUM; OF-THE-ART; IN-VITRO; TRANSDERMAL DELIVERY; PHYSICOCHEMICAL PROPERTIES; ULTRADEFORMABLE CARRIERS; PERCUTANEOUS-ABSORPTION; LIPOSOMES PENETRATE; ENHANCED DELIVERY; TOPICAL DELIVERY;
D O I：
10.2174/1381612821666150428125812
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical methods, aimed at reversibly altering skin permeability in favour of compounds, has been reported. Of the many chemical approaches that exist, one comprises the use of vesicular carriers for delivering drugs into and possibly through the skin. This review offers an overview of various vesicles that have been investigated during dermal and transdermal drug delivery research in recent years, with special emphasis on a relatively new carrier, namely the Pheroid (TM). The progress made to date by our research group with regards to the use of the Pheroid (TM) as transdermal delivery vector, is also discussed in detail.
引用
收藏
页码：2758 / 2770
页数：13
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