A Novel Ferroptosis-Related 4-Gene Prognostic Signature for Cholangiocarcinoma and Photodynamic Therapy

被引:21
|
作者
Zhang, Zi-jian [1 ]
Huang, Yun-peng [1 ]
Li, Xiao-xue [1 ]
Liu, Zhong-tao [1 ]
Liu, Kai [1 ]
Deng, Xiao-feng [1 ]
Xiong, Li [1 ]
Zou, Heng [1 ]
Wen, Yu [1 ]
机构
[1] Cent South Univ, Dept Gen Surg, Xiangya Hosp 2, Changsha, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词
ferroptosis; photodynamic therapy; cholangiocarcinoma; prognosis; ROS; reactive oxygen species; CANCER-CELLS; EXPRESSION;
D O I
10.3389/fonc.2021.747445
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cholangiocarcinoma is the second most common malignant tumor in the hepatobiliary system. Compared with data on hepatocellular carcinoma, fewer public data and prognostic-related studies on cholangiocarcinoma are available, and effective prognostic prediction methods for cholangiocarcinoma are lacking. In recent years, ferroptosis has become an important subject of tumor research. Some studies have indicated that ferroptosis plays an important role in hepatobiliary cancers. However, the prediction of the prognostic effect of ferroptosis in patients with cholangiocarcinoma has not been reported. In addition, many reports have described the ability of photodynamic therapy (PDT), a potential therapy for cholangiocarcinoma, to regulate ferroptosis by generating reactive oxygen species (ROS). By constructing ferroptosis scores, the prognoses of patients with cholangiocarcinoma can be effectively predicted, and potential gene targets can be discovered to further enhance the efficacy of PDT. In this study, gene expression profiles and clinical information (TCGA, E-MTAB-6389, and GSE107943) of patients with cholangiocarcinoma were collected and divided into training sets and validation sets. Then, a model of the ferroptosis gene signature was constructed using least absolute shrinkage and selection operator (LASSO)-penalized Cox regression analysis. Furthermore, through the analysis of RNA-seq data after PDT treatment of cholangiocarcinoma, PDT-sensitive genes were obtained and verified by immunohistochemistry staining and Western blot. The results of this study provide new insight for predicting the prognosis of cholangiocarcinoma and screening target genes that enhance the efficacy of PDT.
引用
收藏
页数:16
相关论文
共 50 条
  • [1] A Novel Prognostic Model Based on Ferroptosis-Related Gene Signature for Bladder Cancer
    Yang, Libo
    Li, Chunyan
    Qin, Yang
    Zhang, Guoying
    Zhao, Bin
    Wang, Ziyuan
    Huang, Youguang
    Yang, Yong
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [2] Identification of a ferroptosis-related gene signature for predicting the prognosis of cholangiocarcinoma
    Wang, Ziyi
    Zhang, Yaodong
    Chen, Yananlan
    Liu, Shuochen
    Li, Changxian
    Li, Xiangcheng
    EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2022, 16 (02) : 181 - 191
  • [3] Exploration and validation of a novel ferroptosis-related gene signature predicting the prognosis of intrahepatic cholangiocarcinoma
    Yao, Xinfei
    Chen, Bo
    Wang, Mingxun
    Zhang, Sina
    He, Bangjie
    Shi, Zhehao
    Deng, Tuo
    Bao, Wenming
    Wang, Yi
    Chen, Gang
    Bo, Zhiyuan
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 54 (09) : 1376 - 1385
  • [4] Immune infiltration and a ferroptosis-related gene signature for predicting the prognosis of patients with cholangiocarcinoma
    Wang, Zhijian
    Chen, Xuenuo
    Jiang, Zheng
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2022, 14 (02): : 1204 - 1219
  • [5] A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma
    Jin, Jingjing
    Liu, Chuan
    Yu, Shanshan
    Cai, Lingyi
    Sitrakiniaina, Andriamifahimanjaka
    Gu, Ruihong
    Li, Wenfeng
    Wu, Fangfang
    Xue, Xiangyang
    AGING-US, 2021, 13 (12): : 16144 - 16164
  • [6] A Ferroptosis-Related Gene Signature Identified as a Novel Prognostic Biomarker for Colon Cancer
    Qi, Xin
    Wang, Rui
    Lin, Yuxin
    Yan, Donghui
    Zuo, Jiachen
    Chen, Jiajia
    Shen, Bairong
    FRONTIERS IN GENETICS, 2021, 12
  • [7] Identification and validation of a novel ferroptosis-related gene signature for prognosis and potential therapeutic target prediction in cholangiocarcinoma
    Sae-fung, Apiwit
    Mutirangura, Apiwat
    Jitkaew, Siriporn
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [8] Identification of a novel five ferroptosis-related gene signature as a promising prognostic model for breast cancer
    Cheng, Tian-cheng
    Wu, Jia-hao
    Zhu, Bei
    Gao, Hai-yan
    Zheng, Lin
    Chen, Wei-xian
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (18) : 16779 - 16795
  • [9] Identification of a Novel Ferroptosis-Related Gene Prognostic Signature in Bladder Cancer
    Sun, Jiale
    Yue, Wenchang
    You, Jiawei
    Wei, Xuedong
    Huang, Yuhua
    Ling, Zhixin
    Hou, Jianquan
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [10] Identification of the ferroptosis-related prognostic gene signature in mesothelioma
    Wang, Zairui
    Huang, Jialin
    Yang, Min
    Fu, Liren
    Liu, Shijie
    Huang, Jianghua
    Han, Jingjing
    Zhao, Xiaohui
    GENE, 2024, 919