Endoplasmic Reticulum Stress, Redox, and a Proinflammatory Environment in Athero-Susceptible Endothelium In Vivo at Sites of Complex Hemodynamic Shear Stress

被引：36

作者：

Davies, Peter F. ^{[1
,2
]}

Civelek, Mete ^{[2
,3
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19041 USA

[2] Univ Penn, Inst Med & Engn, Philadelphia, PA 19041 USA

[3] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 15卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; UNFOLDED PROTEIN RESPONSE; INFLAMMATORY RESPONSE; OXIDATIVE STRESS; DISTURBED FLOW; CELLS; ACTIVATION; ATHEROSCLEROSIS; PATHWAY; EXPRESSION;

D O I：

10.1089/ars.2010.3741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial phenotype heterogeneity plays an important role in the susceptibility of arteries to atherosclerosis. Regions of blood flow disturbance correlate with the development of disease. Here, we briefly outline the association of endoplasmic reticulum stress with endothelium in regions of athero-susceptibility in vivo. It is an important example of susceptible cell phenotype that is likely linked to proinflammatory and oxidative stress pathways. The endothelium in such regions is chronically exposed to complex hemodynamic shear stresses that may be considered as a risk factor for atherosclerosis via these mechanisms. Antioxid. Redox Signal. 15, 1427-1432.

引用

页码：1427 / 1432

页数：6

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