Risk factors of skip lateral cervical lymph node metastasis in papillary thyroid carcinoma: a systematic review and meta-analysis

被引:17
作者
Zhao, Lingqian [1 ]
Wu, Fan [1 ]
Zhou, Tianhan [1 ]
Lu, Kaining [2 ]
Jiang, Kecheng [1 ]
Zhang, Yu [2 ]
Luo, Dingcun [2 ]
机构
[1] Zhejiang Chinese Med Univ, Clin Med Coll 4, Hangzhou 310053, Peoples R China
[2] Zhejiang Univ, Sch Med, Dept Surg Oncol, Affiliated Hangzhou Peoples Hosp 1, Hangzhou 310006, Peoples R China
关键词
Papillary thyroid carcinoma; Skip lateral cervical lymph node metastasis; Lateral cervical lymph node metastasis; Meta-analysis; PREDICTIVE FACTORS; CANCER; MANAGEMENT; RECURRENCE; SURVIVAL;
D O I
10.1007/s12020-021-02967-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To analyze and explore the risk factors of skip lateral cervical lymph node metastasis (SLLNM) in papillary thyroid carcinoma (PTC). Methods PubMed, Web of Science, Embase, Cochrane, Wanfang, China National Knowledge Infrastructure, and China Science and Technology Journal databases, updated to April 4, 2021, were systematically searched for literature on the risk factors of SLLNM in PTC. The meta-analysis was completed using Stata 15.0 software after quality evaluation. The odds ratio (OR) and 95% confidence interval (CI) of each variable were calculated using fixed or random-effects models, and the publication bias was evaluated by the Egger's test. Results A total of 28 studies with 10,682 cases were included in our meta-analysis; 1592 (14.90%) cases were positive for SLLNM. The meta-analysis showed that female sex (OR = 1.16, 95% CI = 1.02-1.31, P = 0.021), age >= 45 (OR = 1.60, 95% CI = 1.19-2.15, P = 0.002), tumor diameter <= 10 mm (OR = 2.23, 95% CI = 1.62-3.06, P < 0.001), and upper location of tumor (OR = 3.60, 95% CI = 2.65-4.89, P < 0.001) were risk factors for SLLNM in PTC patients. Hashimoto's thyroiditis (OR = 1.02, 95% CI = 0.88-1.19, P = 0.777), multifocality (OR = 0.98, 95% CI = 0.75-1.28, P = 0.873), bilateral tumors (OR = 0.92, 95% CI = 0.70-1.19, P = 0.515), extrathyroidal extensions (OR = 1.07, 95% CI = 0.83-1.39, P = 0.598), and capsular invasion (OR = 0.93, 95% CI = 0.65-1.31, P = 0.660) were not closely related to SLLNM risk. Conclusion This study confirmed significant associations between SLLNM and female sex, age >= 45, tumor diameter <= 10 mm, and upper location of the tumor.
引用
收藏
页码:351 / 359
页数:9
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