Biocompatible mesoporous silica nanoparticles with different morphologies for animal cell membrane, penetration

被引：225
作者：
Trewyn, Brian G.
Nieweg, Jennifer A.
Zhao, Yannan
Lin, Victor S. -Y. [1 ]
机构：
[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA
[2] Iowa State Univ, US DOE, Ames Lab, Ames, IA 50011 USA
来源：
CHEMICAL ENGINEERING JOURNAL | 2008年 / 137卷 / 01期
基金：
美国国家科学基金会;
关键词：
mesoporous silica nanoparticle; endocytosis; nanosphere; nanotube; cell membrane; intracellular delivery;
D O I：
10.1016/j.cej.2007.09.045
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Two MCM-41 type, fluorescein-labeled mesoporous silica nanomaterials (MSNs) consisting of spherical and tube-shaped particles were synthesized and characterized. Both materials have hexagonally arranged mesopores with high surface area (>950 m(2)/g) and a narrow distribution of pore diameters. The cellular uptake efficiency and kinetics of both MSNs were measured in a cancer cell line (CHO) and a noncancerous cell line (fibroblasts) by flow cytometry and fluorescence confocal microscopy. The correlation between the particle morphology and aggregation of MSNs to the effectiveness of cellular uptake was investigated. We envision that our study on the morphology dependent endocytosis of MSNs would lead to future developments of efficient transmembrane nanodevices for intracellular sensing and gene/drug delivery. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：23 / 29
页数：7
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